The INDRA Database

sparser

"As stated earlier, RKIP can bind to Raf-1 or MEK, yet not at the same time, and binding to either one is enough to cause downstream inhibition [28] ."

15151133

➶

sparser

"The binding of RKIP to both Raf-1 and MEK inhibits their phosphorylation and activation, thus leading to downstream suppression of the Raf-1-induced signaling and activity of AP-1-dependent transcription [ xref ]."

| PMC

➶

sparser

"RKIP directly interacts with both RAF1 and MEK, and disrupts the RAF1/MEK interaction, thereby preventing the activation of MEK and downstream components of the signaling cascade."

23227430

➶

sparser

"Furthermore, it was shown that Raf-1 and RKIP bind to different sites on MEK."

| PMC

➶

sparser

"Interestingly, it was further shown that MEK and Raf-1 bind to the same sites on RKIP, even though MEK and RKIP are associated with different domains on Raf-1."

| PMC

➶

sparser

"RKIP binds Raf-1 and MEK [81] ."

12781369

➶

sparser

"As stated earlier, RKIP can bind to Raf-1 or MEK, yet not at the same time, and binding to either one is enough to cause downstream inhibition. xref In addition, it was postulated that RKIP may be involved in growth, transformation, and differentiation, xref which are often deregulated in many forms of cancer."

21984962

➶

sparser

"Mechanistically, RKIP binds both CRAF and MEK."

31744053

➶

sparser

"RKIP binds to Raf-1 and MEK, and more weakly to ERK."

18294816

➶

sparser

"More specifically, Raf-1 is bound by RKIP at the phosphorylated N-terminal, which blocks the binding of MEK [ xref ]."