IndraLab

Statements

USP2 deubiquitinates PER1. 6 / 7
1 | 6
reach
"USP2 is essential to deubiquitinating PER1, CRY1 and CRY2 in vivo [54–57]."
32705594
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"Deubiquitination of PER1 by USP2 does not stabilize it."
23213472
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"In light of the shorter half-life of USP2 (compared to that of PER1) (XREF_FIG) and of its rhythmic expression peaking almost simultaneously with that of PER1, the deubiquitination of PER1 by USP2 could be restricted to a specific circadian time and therefore be altering the function and/or localization of PER1 to fine tune the molecular clock in physiological conditions."
23213472
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"The USP2 protein binds and deubiquitinates PER1, regulating its nuclear localization [31,78]."
40002179
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"Further, USP2 is able to deubiquitinate the ubiquitinated forms of the clock proteins BMAL1 (Scoma et al. 2011), PER1 (Yang et al. 2012) and CRY1 (Tong et al. 2012)."
39967311
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"Our previous studies have shown that PER1 is deubiquitinated by USP2 (Yang et al. 2012)."
39967311