IndraLab

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USP2 deubiquitinates PER1. 4 / 4
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"In light of the shorter half-life of USP2 (compared to that of PER1) (XREF_FIG) and of its rhythmic expression peaking almost simultaneously with that of PER1, the deubiquitination of PER1 by USP2 could be restricted to a specific circadian time and therefore be altering the function and/or localization of PER1 to fine tune the molecular clock in physiological conditions."
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"Recently, we showed that the deubiquitinating enzyme ubiquitin-specific peptidase 2 (USP2) associates with clock proteins and deubiquitinates PERIOD1 (PER1) but does not affect its overall stability."
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"Deubiquitination of PER1 by USP2 does not stabilize it."
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"USP2 is essential to deubiquitinating PER1, CRY1 and CRY2 in vivo [54–57]."
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