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USP22 increases the amount of VIM. 8 / 8
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"Western blot analysis showed that USP22 knockdown in H1650 suppressed expression of the mesenchymal markers N-cadherin and vimentin and increased expression of the epithelial markers E-cadherin and al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"AP4 down-regulation partially reversed the increases in N-cadherin and vimentin expression levels induced by USP22 up-regulation; however, no changes in USP22 expression levels were observed."
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"Molecular analysis of the tumor tissues showed that USP22 knockdown reduced the levels of cyclin D2, Akt phosphorylation, vimentin, and Bcl-2, whereas upregulated the expressions of E-cadherin, Bax, and cleaved (cl)-caspase-3, which confirmed in vitro findings."
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"The results showed that USP22 knockdown significantly decreased the mRNA levels of MSRB3 and VIM, but had no obvious effect on that of MMP14 (Fig. 2J, K)."
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"WB results further showed that USP22 overexpression downregulated E-cadherin and ZO-1 expression, upregulated Vimentin expression ( Fig. 6 C), and upregulated the expression of TGF-β1 and ECM componen[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, knockdown of USP22 effectively decreased the expression levels of Vimentin and Twist proteins, and increased those of E-cadherin protein in DDP-resistant TNBC cells ( Figure 2 G and Suppleme[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"IHC staining and WB results also showed that USP22 deficiency increased the protein expressions of E-cadherin and ZO-1, decreased the protein expression of α-SMA and Vimentin ( Fig. 10 C and D), and r[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In HG-treated NRK-52E cells, USP22-FLAG overexpression further increased USP22 expression ( Fig. 3 C), downregulated E-cadherin and ZO-1expression, and upregulated Vimentin expression ( Fig. 3 D)."
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