IndraLab

Statements

SNAI1 binds USP17L2. 29 / 29
10 | 2 17
sparser
"The interaction of Snail with Dub3 is mediated at the N-terminal region of Snail, which holds the SNAG domain and is the most common binding site for E3[ xref ]."
29147673
biogrid
No evidence text available
28198361
biogrid
No evidence text available
28067227
biogrid
No evidence text available
28198361
biogrid
No evidence text available
28198361
reach
"By blocking the interaction of Dub3 and Snail, WP1130 prevents the deubiquitination of Snail, thereby blocking cancer invasion, migration, and the establishment of CSC like properties."
29147673
sparser
"However, only Dub3 interacted with Snail1 in the co-immunoprecipitation (IP) assay ( xref )."
28198361
sparser
"We confirmed the endogenous SNAIL1–DUB3 interaction by co-immunoprecipitation in both MDA-MB-231 and BT-549 cells ( xref ; xref )."
28067227
biogrid
No evidence text available
28198361
sparser
"The interaction between Dub3 and Snail1 was further confirmed by immunofluorescence (IF) analysis showing that endogenous Dub3 co-localized with Snail1 in the nucleus of MDA-MB231 cells ( xref )."
28198361
sparser
"The interaction of Dub3 with Snail1 suggests that Dub3 regulates the protein stability of Snail1."
28198361
sparser
"To identify the region in Snail1 that associates with Dub3, we generated two deletion mutants of Snail1 (refs xref , xref ): the N-terminal Snail1 (amino acids 1–153), which contains the SNAG domain of Snail1; and the C-terminal Snail1 (amino acids 153–264), which includes the conserved zinc finger motif ( xref )."
28198361
biogrid
No evidence text available
28067227
sparser
"Dub3 interacts with Snail1."
28198361
sparser
"By blocking the interaction of Dub3 and Snail, WP1130 prevents the deubiquitination of Snail, thereby blocking cancer invasion, migration, and the establishment of CSC-like properties."
29147673
biogrid
No evidence text available
28067227
sparser
"Moreover, GST-DUB3 could interact with recombinant His-SNAIL1 in vitro , indicating a direct interaction between DUB3 and SNAIL1 ( xref )."
28067227
biogrid
No evidence text available
28198361
reach
"Our study demonstrates that NXN, DUB3 and Snail complex functioned as an important regulatory mechanism of HCC progression and indicates a potential therapeutic approach for the treatment of HCC metastasis."
35927236
sparser
"In both cases, the ultimate target was the Dub3-Snail interaction, suggesting critical role of Dub3-Snail axis in cancer progression and metastasis ( xref )."
29147673
biogrid
No evidence text available
28067227
sparser
"It has been reported that SNAG motif is responsible for interaction of Snail with Dub3, a member of USP subfamily xref ."
29162839
sparser
"Taken together, our results indicate that Dub3 interacts with Snail1 and that this interaction is mediated through the N-terminal regions of Dub3 and N-terminal region of Snail1."
28198361
sparser
"As a bona fide SNAIL1 deubiquitinase, DUB3 interacts with SNAIL1, and then specifically removes the K48-linked ubiquitin chain to stabilize SNAIL1."
34072267
biogrid
No evidence text available
28067227
sparser
"The interaction of DUB3 and SNAIL1 prompted us to examine a potential role for DUB3 in the regulation of SNAIL1 stability and function."
28067227
sparser
"To further investigate the interaction of Dub3 with Snail1, we co-expressed Flag-Dub3 and HA-Snail1 in HEK293 cells and performed a co-IP experiment."
28198361
sparser
"However, when the C-terminal mutant was utilized, Dub3 was unable to interact with Snail1."
28198361
sparser
"Based on Dub3’s dual role in regulating tumor growth and metastasis, future clinical and pharmaceutical investigations could be directed towards this specific interaction of Dub3-Snail."
29147673