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SCN5A activates DYM. 1 / 1
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eidos
"It is possible that the let-7f driven decrease in NaV1.5 current density may cause decreased SMC and cardiomyocyte contractility via an imbalance in the function of Na + / K + pump or Na + / Ca2 + exchanger , like in vascular smooth muscle [ 62 ] , ultimately leading to decreased [ Ca2 + ] i. Another possibility is via NaV1.5 role as the central component of a macromolecular complex that contributes to myocyte structure by interacts with structural genes , like syntrophin and telethonin , both in the heart [ 63 ] and GI smooth muscle [ 60,61 ] ."