IndraLab

Statements

CYLD activates miR-181b. 6 / 6
| 6
reach
"To determine whether CYLD is direct target of miR-181b, we engineered the 3 '-UTR fragments, in which wild-type and mutant binding sites were inserted into the region immediately downstream of the luciferase reporter gene."
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"Luciferase assays indicated that miR-181b can bind with its putative target site in the 3 '-untranslated region (3 '-UTR) of CYLD, suggesting that CYLD is a direct target of miR-181b."
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"Luciferase reporter assays revealed that CYLD is a target of miR-181b."
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"Luciferase assays were used to evaluate activity which CYLD is a target of miR-181b."
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"These results further suggest that CYLD is a target of miR-181b."
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"These data further support the notion that there is a positive and mutual regulation between STAT3 and miR-181b and that CYLD is a target of miR-181b."
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