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SDC4 binds GPNMB. 20 / 25
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"The interaction between Syndecan-4 and GPNMB further leads to a reduction of proinflammatory cytokine secretion and hinders T cells from entering the S phase of the cell cycle ."
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"Of note, GPNMB was packaged into sEVs derived from HCC cells and bound to the surface receptor SDC4 of CD8 + T cells, resulting in the inhibition of CD8 + T cell activation."
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"Our finding suggests that GPNMB may inhibit the activation of CD8 T cells via its packaging into sEVs.Next, we examined whether GPNMB located on the surface of sEVs could bind to SDC4, which is a receptor protein of CD8 T cells."
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"Binding of GPNMB to syndecan-4 is thought to take place in two steps: initial binding via the extracellular arginylglycylaspartic acid (RGD-) domain facilitates PKD-dependent binding [ xref ]."
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"Moreover, the binding of soluble GPNMB to syndecan-4 impedes the extravasation of activated T cells into inflamed skin xref ."
38585871
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"Syndecan-4 is an important molecule for the activation of T cells, and GPNMB can bind to syndecan-4, inhibiting T cell activation."
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"In addition, GPNMB interacts with syndecan-4 on activated T cells through the PKD, which leads to suppression of T cell activation and proliferation ( xref )."
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"Moreover, the binding of soluble GPNMB to syndecan-4 impedes the extravasation of activated T cells into inflamed skin ."
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"In the immune system, GPNMB shows relevant inhibitory effects: DCs and MDSC express GPNMB that binds to syndecan-4 on T cells and suppresses their activation and tissue infiltration by retaining T lymphocytes adherent to endothelial cells [ xref , xref – xref ]."
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"GPNMB-bound SDC4 utilizes membrane protein tyrosine phosphatase CD148 to inhibit T-cells, a mechanism distinct from that of PDL1 and other immune checkpoints xref ."
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"GPNMB binding to the syndecan-4 (SD-4) receptor on activated T cells causes transforming growth factor-β (TGF-β) to become trapped on the cell surface ."
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"XREF_BIBR, XREF_BIBR GPNMB binding to syndecan-4 leads to the recruitment of syntenin and the CD148 protein tyrosine phosphatase, the activation of which occurs following complex formation and is required for syndecan-4 mediated suppression of T-cell activation."
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"In the immune system, GPNMB shows relevant inhibitory effects: DCs and MDSC express GPNMB that binds to syndecan-4 on T cells and suppresses their activation and tissue infiltration by retaining T lymphocytes adherent to endothelial cells [10, 23–25]."
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"With its extracellular heparin and integrin binding motifs, Gpnmb, expressed by both resident and newly-infiltrating tissue macrophages [ 4 , 9–11 ], binds other cell types via its receptors CD44 [ 12[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The critical role of GPNMB-syndecan-4 interaction between antigen presenting cells and T cells has been suggested in different disease models, such as graft-versus-host disease, experimental autoimmune encephalomyelitis (EAE), and cancer ( xref , xref – xref , xref )."
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"GpNMB on antigen presenting cells inhibits T-cell activation by binding to syndecan-4 (SD-4) on T cells 45, 46."
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"The interaction between Syndecan-4 and GPNMB further leads to a reduction of proinflammatory cytokine secretion and hinders T cells from entering the S phase of the cell cycle xref ."
38822058
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"Instead of successfully infiltrating the inflamed skin, T cells were bound by endothelial cells that also expressed syndecan-4 [ xref ], suggesting that the GPNMB–Syndecan-4 axis is responsible for physically orchestrating this critical immune response."
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"GPNMB can suppress T cell activation and proliferation by binding to syndecan-4 on the surface of activated T cells, an interaction that requires an intact PKD domain in GPNMB ( Chung, Dougherty, Cruz[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Cell surface GPNMB and the soluble GPNMB ectodomain also interact with syndecan-4 on T cells to suppress T cell function and proliferation ( xref ; xref ) ( xref )."
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