IndraLab

Statements

SDC4 binds GPNMB. 6 / 11
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"XREF_BIBR, XREF_BIBR GPNMB binding to syndecan-4 leads to the recruitment of syntenin and the CD148 protein tyrosine phosphatase, the activation of which occurs following complex formation and is required for syndecan-4 mediated suppression of T-cell activation."
23874106
reach
"GpNMB on antigen presenting cells inhibits T-cell activation by binding to syndecan-4 (SD-4) on T cells 45, 46."
27642553
sparser
"The critical role of GPNMB-syndecan-4 interaction between antigen presenting cells and T cells has been suggested in different disease models, such as graft-versus-host disease, experimental autoimmune encephalomyelitis (EAE), and cancer ( xref , xref – xref , xref )."
32445534
sparser
"Binding of GPNMB to syndecan-4 is thought to take place in two steps: initial binding via the extracellular arginylglycylaspartic acid (RGD-) domain facilitates PKD-dependent binding [ xref ]."
30586924
sparser
"In addition, GPNMB interacts with syndecan-4 on activated T cells through the PKD, which leads to suppression of T cell activation and proliferation ( xref )."
32445534
sparser
"Syndecan-4 is an important molecule for the activation of T cells, and GPNMB can bind to syndecan-4, inhibiting T cell activation."
34054862