IndraLab

Statements

CYLD inhibits response. 5 / 5
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"It is possible that CYLD may inhibit Akt-mediated fibrotic response by actually deubiquitinating TRAF6."
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sparser
"As shown in xref , CYLD knockdown, using siCYLD, still enhanced TGF-β-induced fibrotic response in TRAF6-depleted cells, thereby suggesting that CYLD inhibits Akt-mediated fibrotic response at least in part by directly interacting with and deubiquitinating Akt."
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sparser
"Thus, we next explored the possibility that CYLD may inhibit Akt-mediated fibrotic response via deubiquitinating TRAF6."
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sparser
"Nonetheless, these data demonstrate that CYLD indeed inhibits Akt-mediated fibrotic response by at least in part directly interacting with and deubiquitinating Akt."
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eidos
"For example , CYLD removes polyubiquitin chains from TBK1 and RIG-I and thus inhibits the IRF3 signaling pathway and IFN production triggered by RIG-I ; conversely , CYLD knockdown enhances this response ( 58 ) ."
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