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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SCN5A activates PMCA4b. 1 / 1

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"Based on these data, we speculate that the three mutations may disturb the interaction of PMCA4b and SNTA1 in the whole macromolecular complex SCN5A, nNOS, SNTA1, and PMCA4b, thus relieving the negative regulation of PMCA4b on nNOS, and thereby resulting in an increase of local NO concentrations and a biophysical modification of the sodium channel."

20009079

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...