IndraLab

Statements

UCHL1 decreases the amount of MITF. 4 / 4
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"The above two experiments suggested that UCHL1 interacted with ubiquitinated MITF and reduced MITF protein levels by increasing polyubiquitinated MITF.To further validate whether UCHL1 decreased MITF [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, because the mutant form of UCHL1, which showed reduced or no enzyme activity, did not significantly decrease MITF protein levels, it is possible that UCHL1 functions as an ubiquitin ligase to[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The ligase activity of UCHL1 is disrupted in PD, resulting in MITF overexpression and cell damage in these patients (Liu et al. 2002; Seo et al. 2017)."
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"Furthermore, UCHL1 reduced the protein, but not mRNA, levels of MITF, the upstream regulator of tyrosinase, dopachrome tautomerase, and tyrosinase related protein-1."
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