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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Modified HSP90 increases the amount of KCNQ4. 1 / 1

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"Therefore, our data confirmed that decreased cell surface expression and impaired conductance of the KCNQ4 channel are two independent mechanisms underlying hearing loss in DFNA2; that restoration of KCNQ4 surface expression by overexpression of HSP90 was not sufficient to rescue the channel function in HEK293T cells mimicking the heterozygous condition of DFNA2 patients."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...