IndraLab

Statements

SRC phosphorylates MAP2K1 on S298. 5 / 8
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"Because Src-dependent MEK1 S298 phosphorylation is required for adhesion-mediated activation of MEK ( xref ) and subsequent MAPK activation ( xref ), we examined the effect of Src inhibition on phospho-MAPK localization in REF52 cells."
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sparser
"FAK and Src positively regulate phosphorylation of MEK1 on S298 by PAK1."
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reach
"We propose that FAK and Src dependent, PAK1 mediated phosphorylation of MEK1 on S298 is central to the organization and localization of active Raf-MEK1-MAPK signaling complexes, and that formation of such complexes contributes to the adhesion dependence of growth factor signaling to MAPK."
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reach
"We propose that FAK and Src dependent PAK phosphorylation of MEK1 on S298 is central to the organization and localization of active Raf-MEK1-MAPK signaling complexes and that formation of such complexes underlies the observed adhesion dependence of growth factor signaling to MAPK."
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reach
"Inhibition of Src family kinases with PP2 not only inhibited MEK1 S298 phosphorylation, but also decreased phosphorylation of both MEK and MAPK on their respective activating sites in response to adhesion."
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