IndraLab

"Lysine (K) and arginine (R) residues in p53 can be methylated, and a growing number of studies in recent years have shown that p53 methylation takes place during the DNA damage response. xref – xref Methylation of lysine and arginine residues in histones has long been known to impact chromatin structure and gene expression. xref In recent years, the methylation of p53 has emerged as an important modification that affects its function in various processes, such as cell cycle arrest, DNA repair, senescence, apoptosis, and tumourigenesis. xref Whether p53 is activated or depressed depends on the location of the modification and the number of methyl groups attached. xref Protein arginine N -methyl transferase 5 (PRMT5) was first shown to methylate p53 at several arginine residues (R333, R335, and R337) in the tetramerization domain, xref which specifically controls the functions of p53 in cell cycle arrest and is suggested to inactivate p53 during lymphomagenesis. xref , xref There are three different lysine methyl transferases (KMTs) that could mono-methylate p53, and there are at least two KMTs could di-methylate p53. xref "

"Methylated p53 arginine residues affect p53 response by influencing the specificity of p53 binding to promoters [ xref ]."