IndraLab

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"However, the underlying mechanisms for USP10 interacting with EIF4G1 and regulatory functions in NSCLC still require further investigation."

"By using co-immunoprecipitation and immunofluorescence approaches, we further confirmed the interaction of EIF4G1 and USP10 in H1299 cells (Figure xref )."

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"There is a recent report that USP10 interacts with eIF4G1 and depletion of USP10 enhanced eIF4G1 protein levels( xref )."

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"It was reported that EIF4G1 interacted with the ubiquitin USP10, as shown by tandem affinity purification and mass spectrometry; USP10 is located in the cytoplasm, and USP10 had been shown to be able to specifically ubiquitin and stabilize p53, thereby regulating p53‐dependent downstream function. xref , xref , xref To date, p53 is one of the most important tumour suppressor factors. xref As a transcription factor, p53 regulates a variety of cytological responses by regulating downstream target genes. xref , xref For example, p53 regulates cell cycle G1 arrest by acting on the CDK inhibitory factor p21, cell apoptosis by acting on bax, energy metabolism by acting on TIGAR of glycolysis, and autophagy by acting on AMPK."

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