IndraLab

Statements

USP10 binds Tax. 10 / 10
| 3 7
sparser
"We found that interaction of Tax with USP10 inhibits arsenic-induced SG formation, stimulates ROS production, and augments ROS-dependent apoptosis in HTLV-1-infected T cells."
23775713
sparser
"In adult T-cell leukemia (AML), previous studies have revealed that the human T-cell leukemia virus type 1 (HTLV-1) oncoprotein Tax interacts with USP10 and promotes ROS-dependent apoptosis and the occurrence of AML."
35627217
sparser
"Tax also interacts with USP10, inhibiting SG assembly and enhancing the production of reactive oxygen species [227]."
27367717
sparser
"The interaction between Tax and the deubiquitinase USP10 is one of the molecular mechanisms that leads to Tax-mediated induction of ROS [ xref ]."
35169839
sparser
"Tax also interacts with the deubiquitinase USP10 to stimulate ROS production, which can contribute to Tax driven-senescence in HTLV-1-infected T cells [ xref ]."
32645846
reach
"Tax also interacts with USP10, inhibiting SG assembly and enhancing the production of reactive oxygen species [XREF_BIBR]."
27367717
sparser
"Tax mutants and USP10-knockdown indicated that Tax inhibits arsenic-induced SG formation, stimulates ROS production and augments ROS-dependent apoptosis, and they are all dependent on interactions of Tax with USP10."
| PMC
reach
"Tax also interacts with the deubiquitinase USP10 to stimulate ROS production, which can contribute to Tax driven-senescence in HTLV-1-infected T cells [XREF_BIBR]."
32645846
sparser
"Tax also interacts with USP10, inhibiting SG assembly and enhancing the production of reactive oxygen species [ xref ]."
27367717
reach
"A curved arrowhead with a black color indicates positive regulation.In addition to USP10 being regulated by the proteins of host cells, previous studies of the Takahashi group showed that HTLV-1 Tax interacted with amino acids 727–798 at the C-terminal of USP10 and inhibited USP10’s deubiquitination activity and function."
35627217