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Selenium atom leads to the methylation of TP53. 4 / 4
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"Taken together, long-term Se consumption not only affects selenoprotein enzyme activities, homocysteine, tissue Se concentrations, and global genomic DNA methylation but also increases exon specific DNA methylation of the p53 gene in a Se-dose-dependent manner in rat liver and colon mucosa."
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"Furthermore, Se deficiency has been demonstrated to cause global hypomethylation and promoter methylation of the p16 and p53 tumor suppressor genes [XREF_BIBR]."
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"For example, long-term selenium consumption increases exon specific DNA methylation of the p53 gene in rat liver and colon mucosa [XREF_BIBR]."
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"The study whether selenium affects the methylation of the p53 gene was investigated, and it was found that supranutritional dose of selenium significantly increased the exon specific DNA methylation of the p53 gene (in exons 5-8) in liver and colon mucosa of rats compared with this in animals fed with the selenium deficient diet [XREF_BIBR]."
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