IndraLab

Statements

USP6 binds TR. 6 / 6
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"As indicated above, given the limitation of the ChIP assay, it is possible that the weak TR ChIP signal at TRE1 was a result of TR binding at the TRE2 and TRE2 is the only TRE bound by TR during metamorphosis in the intestine and tail."
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"In any case, our findings together indicate that Dot1L gene is a direct T3 target gene that is regulated via binding of the TR predominantly to TRE2."
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"TR is bound to the Dot1L TRE2 in both intestine and tail of premetamorphic tadpoles."
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"That is, TR also bound predominantly to the TRE2 in the tail of premetamorphic tadpoles treated with or without T3 for 2 days."
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"This could occur if the TRE1 region was present in some large fragments of DNA immunoprecipitated due to TR binding to the TRE2."
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"On the other hand, as the DNA generated by sonication during the ChIP assay could be as long as 1 kb (typically averaging around 500 bp), we could not rule out the possibility that the signal observed at TRE1 was due to TR binding at TRE2."
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