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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

OTULIN inhibits IFN-I. 1 / 1

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"Interestingly, liver inflammation observed in OTULIN deficient mice is accompanied by increased expression of IFN response genes [XREF_BIBR] and murine Otulin C129A and C129A Ripk3 -/- Casp8 -/- BMDMs show spontaneous activation of IKKepsilon and TANK binding kinase 1 (TBK1) [XREF_BIBR], indicating that OTULIN suppresses IFN-I production pathways."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...