IndraLab

Statements

Ubiquitin inhibits ZUP1. 5 / 5
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"The ubiquitin variant CC.4 binds to the OTU domain with high affinity and inhibits CCHFV DUB activity [27]."
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"Slopes of linear portions of fluorescent signal formation were used to determine the velocity of substrate cleavage in the presence and absence of ubiquitin variant CC.4 (CC.4) which has been shown previously to inhibit DUB activity of CCHFV isolated OTU-domain [27]."
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"DUB activity of both full length protein and OTU domain is inhibited by ubiquitin variant CC.4."
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"(C) Ubiquitin variant CC.4 inhibits DUB activity of both full length protein and OTU domain to a similar extent as illustrated by the 50% inhibitory concentrations (IC50)."
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"This variation is stated to be advantageous where for example; the DUB to be assayed is inhibited by ubiquitin dimmers [85] ."
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