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IL6 decreases the amount of USP7. 6 / 6
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"We also suggest that IL-6 induced STAT3 activation represses USP7 expression, leading to the degradation of P53."
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"Stimulation of Treg cells with IL-6, lipopolysaccharide (LPS) or heat shock, reduces USP7 expression and increases Stub1 expression, thereby leading to a reduction in FOXP3 protein levels [29,32] ."
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"As a corollary, van Loosdregt et al. (2013) noted that IL-6 inhibits USP7 protein expression, further inhibiting the stability of FOXP3.The biggest limitations of both studies pertain to the in vivo d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As shown in Fig. 2 A and B, IL-6 treatment reduced USP7 levels in SW480 cells in a dose dependent manner."
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"Our data are in accordance with a recent study by XREF_BIBR that reports that, in colon tumors, IL-6 can inhibit USP7 expression in a STAT3 dependent manner."
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"In addition to observing that LPS could disrupt the association between USP7 and Foxp3, Yang et al. (2012) also found that in colon tumours, IL-6 inhibits USP7 expression in a STAT3 dependent manner, and the USP7-Foxp3 association was prolonged by this reduction in USP7 expression."
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