IndraLab

Statements

USP9X activates cell cycle. 13 / 13
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"For example, in triple-negative breast cancer (TNBC), USP9X deubiquitinates and stabilizes PPP1R14B, leading to PPP1R14B overexpression in TNBC tissues, decreasing STMN1-mediated α-microtubule protein acetylation and microtubule stability, and promoting cell cycle progression, leading to paclitaxel resistance in TNBC cells [40]."
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"Similarly, the cell cycle was arrested in the G1 stage by USP9X knockdown (Fig. 4D and E), and extra apoptosis was identified in USP9X-deficient GC cells (Fig. 4F and G)."
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"USP9X promoted proliferation and cell cycle in MCL cells."
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"The results indicate that USP9X overexpression can increase breast cancer cell development by regulating cell cycle progression."
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"Furthermore, our study revealed that the USP9X/CDC123 axis promotes the occurrence and development of breast cancer through regulating the cell cycle, and suggests that it may be a potential target for breast cancer intervention."
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"The results indicate that USP9X overexpression leading to increased breast cancer cell development by regulating cell cycle progression may be associated with the regulation of CCND1 and CDKN1A expression."
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"These results indicated that USP9X promoted proliferation and cell cycle in MCL cells."
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"USP9X was identified to promote proliferation and cell cycle and inhibited cell apoptosis in MCL cells."
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"USP9X further contributes to cell cycle–dependent ciliogenesis; in the G0/G1/S phase, USP9X is recruited to the centrosome by NPHP5, where it protects NPHP5 from ubiquitination, promoting cilia assembly."
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"As transcriptional regulation of c-myc and cyclin D1 may be manifested indirectly by reduced cell cycle progression induced by USP9X knockdown, we need to clarify whether USP9X can regulate c-myc and cyclin D1 levels through the Wnt and beta- catenin pathway."
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"27 Accordingly, our study demonstrated that USP9X increased proliferation and cell cycle in MCL cells."
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"Flow cytometry proved that the cell cycle inhibited by USP9X knockdown was enhanced by CCND1 overexpression."
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"We proved that USP9X overexpression promoted proliferation and cell cycle and suppressed cell apoptosis in MCL cells."
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