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TP53 methylates TP53. 8 / 8
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"Moreover, bilateral partial ligation of the uterine arteries during pregnancy resulted in p53 hypomethylation and elevated expression of Bax and p53 as well as a reduction in Bcl-2 mRNA [XREF_BIBR]."
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"Oncogenic growth of such tumours is associated with reduced p53 activity caused by overexpression of one or more epigenetic regulators that post-translationally modify p53 protein and impair its tumour-suppressor functions, including Aurora A kinase that phosphorylates p53 (S212/S312) and methyltransferases that methylate p53 such as Smyd2 (K370), Glp/G9a (K373) and PR-Set7 (K382)."
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"As p53 is (i) a key regulator of apoptosis and (ii) control the transcription of many apoptosis related-genes, silencing via methylation of p53 binding sites by the Dnmt3a and p53 complex may confer a signature participating in apoptosis resistance."
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"In the present study, we demonstrated that the age at which mice underwent 3-Gy whole-body irradiation leads to differences in TCR VF, percentage of apoptosis, expression of phospho-p53, ratio of the p53 allele and p53 methylation levels at 56 weeks of age (Table xref )."
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"Because transcription factor occupancy can affect DNA methylation levels and DMR1 is within a p53 binding site at the DINO/CDKN1A locus, we examined whether TP53 status is associated with a differential methylation of p53 bound sites elsewhere in the genome (Younger et al., 2015)."
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"QPCR analysis also showed that Mll2 Gdf9 cKO oocytes overexpressed several apoptosis associated genes (XREF_TABLE), including p53 (transformation related protein 53; TRP53) and Setd7 (SET domain lysine methyltransferase 7, also know as Set7/9) (XREF_TABLE and XREF_SUPPLEMENTARY), which methylates p53 and prevents its degradation XREF_BIBR."
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"It was shown that a similar proportion of gliomas with and without P53 mutation present P53 promoter methylation ( xref )."
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"In the present study, we showed that the differences in expression of phospho-p53, the ratio of the p53 allele and p53 methylation levels at 56 weeks of age between mice that underwent 3-Gy whole-body irradiation at various ages (Table xref )."
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