IndraLab

Statements

USP14 inhibits cell death. 6 / 6
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"USP14 downregulation inhibits pyroptotic cell death in AF cells from IVDD patients, suppresses the activation of NLRP3 and regulates related signaling components."
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"USP14 inhibition via gene knockdown or small molecules induces cell death in breast cancer ( 24 ) , acute myeloid leukemia ( 25 ) , and diffuse large B-cell lymphoma ( 26 ) ."
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"Moreover, inhibition or silencing of USP14 dramatically induced higher levels of cell death and PARP cleavage in MDA-MB 231 and MDA-MB 453 than in MCF7 breast cancer cells."
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"b-AP15, a small molecule inhibitor of two 19S regulatory-particle-associated deubiquitinases, USP14 and ubiquitin C-terminal hydrolase 5, could efficiently induce cell apoptosis or cell death in colorectal cancer cell line HCT116.24 In addition, b-AP15 can suppress the growth of FaDu squamous cell carcinoma cells.25 Our stratified survival analysis indicated that high USP14 expression could distinguish poor outcomes of patients with either early (TNM stage I-II) or advanced clinical stage (TNM stage III-IV), suggesting that USP14 may play a significant role throughout the development of ESCC."
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"The deubiquitinating enzyme USP14 lowers both mHTT aggregation and mHTT-induced cell death, which is mediated by the reduced interaction between USP14 and IRE1α in the ER membrane in mHTT-expressing cells and BACHD mice, thereby reducing ER-stress via IRE1α."
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"USP14 inhibits non-homologous DNA end joining (NHEJ) and increases cell death in response to IR in phosphatase and tensin homolog (PTEN)-deficient prostate cancer cells through targeting several NHEJ-associated proteins, including Ku70, Ku80, and ring finger protein 168 (RNF168)."
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