IndraLab

Statements

RPN1 binds USP14. 3 / 3
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"The binding of USP14 to Rpn1 subunit through Ubl enhances its deubiquitinating activity, which is responsible for the removement of ubiquitin chains and prevent the release of ubiquitin to the proteolytic channel."
33542205
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"Interestingly, USP14 and UCH37 bind to RPN1 and to RPN13, respectively, which are, in addition to the RPN10, substrate receptors of the 19S regulatory particle [67], which provide a versatile binding platform for various ubiquitin chains [68]."
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"Both UCHL5 and USP14 are physically associated with the base components of the 19S proteasome; USP14 can bind to the scaffolding protein Rpn1, while UCHL5 is found to bind to both ubiquitin receptors Rpn10 and Rpn13 [XREF_BIBR - XREF_BIBR]."
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