IndraLab

Statements

NRAS activates KRAS. 10 / 10
| 9 1
reach
"Ras has four subtypes viz; Ha-Ras, N-Ras, KiRas 4A and KiRas 4B of which KiRas strongly activates MAPK pathway whereas HaRas more strongly activates PI3K and Akt pathway."
29864503
reach
"Noteably, NRAS knockdown further enhanced inhibition of proliferation in the absence of KRAS (XREF_FIG D)."
30685691
reach
"Taken together, these results show that signaling by H-Ras and N-Ras, but not K-Ras, are required to promote PGA 1 -induced apoptosis."
27468687
reach
"But this ras protein is the product of K-ras and H-ras genes rather than N-ras."
7632727
reach
"This therapeutic concept could also be extended to NRas/BRaf-driven melanomas, BRaf-driven pediatric brain tumors, PTEN-driven prostate cancers and KRas-driven NSCLCs that are all Ras/Raf driven malignancies that rely on autophagy for survival (Lee et al., 2019; Mulcahy Levy et al., 2017; Santanam et al., 2016; Strohecker et al., 2013; Xie et al., 2015)."
31451213
reach
"Such Raichu-KRas probe has been recently used to document the specific activation of K-Ras but not H-Ras or N-Ras on late endosomes thus identifying a mechanism for intracellular signal propagation [XREF_BIBR]."
20538448
sparser
"Within cancer signaling, RAF1 is another obligate RAS effector whose gene effect was a mixture of activated NRAS and activated KRAS, as reflected by the UMAP embedding ( xref ) and loadings ( xref )."
35085500
reach
"We evaluated the efficiency of Kras deletion and oncogenic Nras activation in Kras ; Nras thymocytes on day 37."
33512434
reach
"It is also possible that NRAS may activate different signaling pathways to KRAS and HRAS; an idea supported by the observation that NRAS has greater transforming activity than KRAS in experimental models of melanoma."
23069660
reach
"In contrast to nonresistant cells, NRAS inhibition alone was sufficient to significantly impair proliferation in resistant cells, and NRAS knockdown only slightly and nonsignificantly induced KRAS upregulation."
30685691