IndraLab

Statements

sparser
"These results suggest that the DUB3–cyclin A axis plays a key role in G1/S transition during cell cycle progression and at least partially explain the mechanism of DUB3 which promotes the proliferation of NSCLC cells, providing a promising target for NSCLC treatment [ xref ]."
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sparser
"Mechanistically, DUB3 interacts with cyclin A, which removes the polyubiquitin chains conjugated onto cyclin A and stabilizes the cyclin A protein."
30935108
sparser
"Similar to USP37, DUB3 binds cyclin A, leading to its deubiquitination and stabilization, and regulates the G1/S transition."
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