IndraLab

Statements

Modified USP14 increases the amount of AR. 3 / 3
| 3
reach
"Indeed, both pharmacological and genetic inhibition of USP14 markedly reduced, and conversely USP14 overexpression increased, the steady state protein levels of AR and its target gene PSA in LNcap cells (XREF_FIG)."
28151478
reach
"Loss of USP14 expression and function dramatically decreased AR level, blocked G 0 / G 1 to S phase transition, and triggered cell apoptosis in AR + breast cancer cells, suggesting that targeting USP14/AR axis could be a potential strategy for TNBC therapy."
29353883
reach
"Conversely, overexpression of USP14 increased the expression of AR and PSA and decreased the expression of MDM2 and its phosphorylation (XREF_FIG)."
28151478