IndraLab

Statements


Modified USP14 increases the amount of AR. 3 / 3
| 3

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"Indeed, both pharmacological and genetic inhibition of USP14 markedly reduced, and conversely USP14 overexpression increased, the steady state protein levels of AR and its target gene PSA in LNcap cells (XREF_FIG)."

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"Loss of USP14 expression and function dramatically decreased AR level, blocked G 0 / G 1 to S phase transition, and triggered cell apoptosis in AR + breast cancer cells, suggesting that targeting USP14/AR axis could be a potential strategy for TNBC therapy."

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"Conversely, overexpression of USP14 increased the expression of AR and PSA and decreased the expression of MDM2 and its phosphorylation (XREF_FIG)."