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USP14 increases the amount of Ubiquitin. 2 / 2
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"Similarly, inhibition of USP14 alone by IU1 significantly increased the accumulation of polyubiquitinated proteins by 22.51 +/- 4.44% (P = 0.025, n = 5) and decreased the levels of monomeric ubiquitin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Free Ub, but not Ub conjugate, levels were reduced in the brain of ax J mice, but neuron specific expression of the Usp14 transgene was sufficient to restore free Ub levels in the spinal cord and motor neuron axons and could rescue ataxia phenotypes with defective neuromuscular junctions in ax J mice XREF_BIBR, XREF_BIBR."
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