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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP14 increases the amount of Ubiquitin. 2 / 2

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"Similarly, inhibition of USP14 alone by IU1 significantly increased the accumulation of polyubiquitinated proteins by 22.51 +/- 4.44% (P = 0.025, n = 5) and decreased the levels of monomeric ubiquitin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Free Ub, but not Ub conjugate, levels were reduced in the brain of ax J mice, but neuron specific expression of the Usp14 transgene was sufficient to restore free Ub levels in the spinal cord and motor neuron axons and could rescue ataxia phenotypes with defective neuromuscular junctions in ax J mice XREF_BIBR, XREF_BIBR."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...