IndraLab

Statements

PPP3 activates KCNK18. 8 / 11
| 5 3
reach
"Because inhibiting calcineurin will impair TRESK activation in response to stimuli-induced Ca increase, a higher requirement of this volatile anesthetic will be needed to achieve anesthesia, as recently shown in the knockout mice [61]."
21527011
reach
"Intrathecal application of exogenous calcineurin to tumor-bearing rats rescued TRESK abundance and abrogated both DRG hyperexcitability and pain hypersensitivity, whereas either inhibition or knockdown of calcineurin in normal rats reduced TRESK abundance and increased DRG excitability and pain sensitivity."
30327410
sparser
"It has been shown that an increase of intracellular calcium produced by the calcium ionophore ionomycin, can produce calcineurin-dependent activation of TRESK expressed in Xenopus oocytes xref ."
22355750
reach
"Using a model of pain hypersensitivity in bone cancer–bearing rats, the authors show that intrathecal injection of calcineurin enhances TRESK mRNA and protein expression, as well as TRESK-mediated current [41]."
32717813
sparser
"Intriguingly, dysarthria, restlessness, headache and seizures have been observed in our patients and it is tempting to speculate that these symptoms could be associated, at least in part, with Y163D- and S252L-induced disruption of calcineurin-dependent TRESK channel activation in the brain."
34199759
reach
"This data indicates that calcineurin inhibition deactivates TRESK channels through the suppression of TRESK dephosphorylation but also reduces TRESK protein and mRNA abundance."
32717813
sparser
"TRESK expressed in Xenopus oocytes is strikingly activated by calcineurin in response to calcium mobilizing stimulation xref , xref , and it is assumed that native TRESK in neuronal cells is subject to similar regulation ( xref )."
21115349
reach
"Calcineurin Modulation of TRESK and Pain Sensitivity."
32717813