IndraLab
Statements
AKT activates cell differentiation. 545 / 560
|
5
540
reach
"Akt is phosphorylated and activated via PI3K in response to signals originated by the erythropoietin (EPO) receptor; in particular, Akt is able to support erythroid differentiation in JAK2 deficient fetal liver progenitor cells through a mechanism downstream of EpoR XREF_BIBR and at least in part related to GATA-1 phosphorylation XREF_BIBR."
reach
"In order to determine the purity of the primary astrocyte cultures and to investigate whether the expression of c-Myc and/or Akt induced the expression of neural differentiation markers we performed RPA with a probe set containing neuronal (GAP43, NF68, synaptophysin, calbindin), astrocytic (GFAP) and oligodendroglial (PLP, MBP) genes."
reach
"Combined with the results that Tfh cells had reduced Akt and mTOR signaling compared with Th1 cells in vivo and that overexpression of constitutively active Akt promoted Th1 cell differentiation, that study suggests that in addition to the IL-2/STAT5/Blimp1 axis, the IL-2/Akt/mTOR axis also favors Th1 cell development at the expense of Tfh cells 132."
reach
"A series of studies demonstrated that constitutive Akt hyperactivity driven by the proteolipid protein (Plp) promoter enhances CNS myelination without affecting OPC proliferation, survival, and differentiation (Flores et al., 2008) and the myelination-promoting effect appears to act through mTOR signalling, one of the downstream substrates of Akt (Narayanan et al., 2009; Wahl et al., 2014), specifically through Raptor-containing mTOR complex 1 (mTORC1) (Bercury et al., 2014)."
reach
"To demonstrate whether Akt signalling mediates EPC differentiation, bone marrow derived cells from PPARalpha WT mice were incubated in the absence or presence of either MPs PPARalpha +/+ or MPs PPARalpha-/-, and Akt phosphorylation on Ser 473 indicative for Akt activity was detected by Western blot analysis."
reach
"Most of the studies on IGF-1R signaling have focused on its role in the differential activation of two important intracellular signaling pathways : the MAPK-ERK pathway, which regulates cell proliferation, differentiation, and tissue homeostasis, or the PI3K-AKT cascade, which promotes cell survival, metabolism, antiapoptosis, and differentiation."
reach
"A significant decrease in the p-Akt and Akt ratio was observed in syringin treated cells compared to that of the control (XREF_FIG C); it has been reported that inhibition of Akt phosphorylation and activation blocks adipocyte differentiation of 3T3-L1 cells, and suggests syringin 's ability to inhibit the Akt activation [XREF_BIBR, XREF_BIBR]."
| PMC
reach
"Like NGF, MT2 increased phosphorylation of extracellular signal regulated kinase1/2 and Akt proteins and production of MKP-1 phosphatase (dual specificity phosphatase 1), modulated p38 mitogen activated protein kinase activation, sustained survival of serum starved PC12 or RDG cells, and promoted their differentiation."
reach
"VEGF2 treated EPCs have enhanced AKT activation, and infarcted hearts receiving these VEGF-2 treated EPCs exhibit improved angiogenesis and cardiac function compared with control treated hearts, while inhibition of AKT by Ox-LDL impairs endothelial differentiation in bone marrow stem cells."
reach
"Interestingly, in the absence of NO, the activation of Akt phosphorylation alone by using AKT activator (SC-79) did not profoundly promote the endothelial differentiation of ESCs, suggesting an interdependent relationship between NO and the Akt phosphorylation in driving endothelial fate specification of ESCs."
reach
"Furthermore, knockdown or overexpression of the AKT downstream targets Foxo1 and Foxo3a was found to inhibit or promote iTreg differentiation in PKC-theta (-/-) T cells accordingly, indicating that the AKT-Foxo1/3A pathway is responsible for the inhibition of iTreg differentiation of iTregs downstream of PKC-theta."
reach
"In the ARDS lung, reduced Akt activity in conventional T cells will promote their differentiation to effector Tregs, limiting inflammation and scar formation, and promoting vascular regeneration and wound resolution, revealing the potential therapeutic benefits of Akt inhibitors such as triciribine and MK2206 to treat ARDS in advanced-stage coronavirus disease-2019 (COVID-19) patients."
reach
"In various cell types activation of Ras leads to activation of the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase 1/2 (ERK1/2), and protein kinase B (PKB)/Akt, which exert opposing effects on adipogenesis, with ERK1/2 inhibiting and PKB and Akt promoting terminal differentiation."
reach
"Transgenic overexpression of an activated form of Akt, a downstream target of PI3K, in cartilage increased chondrocyte proliferation in the resting zone, and delayed hypertrophic differentiation in the growth plate, but promoted hypertrophic differentiation in craniobasal cartilaginous elements and vertebrae."
reach
"Because increased levels of PI3K, Akt, mTOR, and metabolic activities support Th17 cell differentiation and inhibit Treg differentiation XREF_BIBR, XREF_BIBR, XREF_BIBR, we examined the possibility that increased expression or activity of RARalpha favors the differentiation of Th17 over that of Treg cells."
reach
"There are similar intracellular segments in different receptor families, which regulate similar signaling pathways and exhibit similar functions, including activation of the PI3/Akt and Erk1/2 signaling pathways to promote cell proliferation, differentiation, migration, and cell cycle progression (16)."
reach
"M-CSF receptor is expressed at low levels on HSCs and at higher levels on monocytes and tissue Mϕs. Its ligation activates PI3K/AKT, Src, PLC-γ, and ERK kinases and SHP-1 phosphatase, promoting cell survival, proliferation, and differentiation (Sherr, 1990; Jack et al., 2009; Stanley and Chitu, 2014) ."
reach
"Among the mentioned nanozymes, the cube enclosed by the (100) facet exhibits the highest CAT-like activity, causing it to provide superior protection to NPCs from oxidative stress induced by H 2 O 2 ; meanwhile, the octahedron enclosed by the (111) facet with the lowest CAT-like activity induces the most ROS production in ReNcell CX cells, which promotes neuronal differentiation by activated AKT/GSK-3β/β-catenin pathways."
reach
"Terminal adipocyte differentiation is promoted by the activity of several kinases, particularly kinases of the PI3K and AKT pathway and those activating p38 mitogen activated protein kinases, and results in the synthesis of adipocyte secreted products, including adiponectin (the most abundant transcript in human adipose tissue) and leptin."
reach
"Given the key role of AKT activation in the transformation of hNSCs and endothelial lineage differentiation of GSC, coupling with the association of high-AKT activation with poor prognosis, we identified a list of genes associated with high AKT activation from our oncogene induced hNSC system (XREF_SUPPLEMENTARY)."
reach
"These data demonstrate that PI3K and AKT inactivation stimulated melanoma GFP high cell differentiation, suggesting that TNF suppresses their commitment to the differentiation fate by activating AKT, consequently preventing asymmetric self-renewal and promoting symmetric self-renewal of GFP high melanoma SCs."
reach
"As reported, zinc could optimize anti-tumour effects by inhibiting LPS-, ROS- or other immune factor induced oncogenic signalling pathways, such as NF-kappaB, activator protein-1, Janus tyrosine kinase and signal transducer and activator of transcription (JAK and STAT), and PI3K and Akt; decrease oxidative stress and inflammatory responses induced by chemo- and radiotherapy; promote the development and differentiation of T and B lymphocytes; and improve the tumour microenvironment to reduce the risk of prostate, oesophageal, lung, and oral cancers [XREF_BIBR - XREF_BIBR]."
reach
"Skurk et al. reported that beta-catenin-enhanced endothelial cell differentiation and migration are inhibited by PI3K and Akt inhibition, suggesting that Wnt and beta-catenin promotes angiogenesis and blood vessel growth via the induction of PI3-K and Akt signaling in endothelial cells [XREF_BIBR]."
reach
"The PI3K and Akt cell signaling cascade is commonly activated in many types of cancers, regulating cell survival, differentiation, proliferation, and apoptosis, and the inhibition of Akt phosphorylation has been deemed as a feasible strategy for the therapeutic treatment against human cancers."
reach
"These results suggest that the PI3K and Akt signaling pathway can promote proliferation and adipogenic differentiation of adipose stem cells, and that activation of this pathway by FGF2 may explain why hbASCs show greater proliferation and adipogenic differentiation than haASCs and htASCs."
reach
"Its down-regulation is directly linked to the reduced phosphorylation of AKT and PKC, which leads to an impaired differentiation of Th2 cells, producing IL-4, IL-5, IL-10, and IL-13, responsible for strong antibody production, eosinophil activation, and inhibition of several macrophage functions, providing phagocyte independent protective responses [XREF_BIBR]."
reach
"Mechanistically, Pi retention is mediated by soluble carrier family 20 member 1 (SLC20A1) and sensed by diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) to enhance Akt activation, which then upregulates SLC20A1 to aggravate Pi retention and augments GATA2 activity to drive the expansion and megakaryocyte/myeloid-biased differentiation of HSCs."
reach
"As Activin/Smad2/3 signaling is required for expression of the pluripotency gene Nanog, these results suggest that robust PI3K and Akt activity collaborates with Activin and Smad signaling to maintain hESC self-renewal, while weak PI3K and Akt activity switches the function of Activin and Smad to promote differentiation."
reach
"The induction of the PI3K pathway and thereby PDK1 and serine/threonine kinase protein kinase B (AKT) pathway, by CCR5, in turn, induces cell survival, glycolysis, cell proliferation, growth and proliferation of progenitor and stem cells, immune cell differentiation, and the release of eIF4E to promote cap dependent translation [XREF_BIBR, XREF_BIBR]."
| PMC
eidos
"6 In summary , OT and AVP activate a complex array of signaling pathways to regulate skeletal muscle homeostasis ( modulating different kinases , modifying the calcium level , through the CaMK / Calcineurin signaling to activate the myogenic regulatory factors expressions , and by stimulating the Akt / mTOR or the MAPK pathway to induce muscle cell proliferation , differentiation , contraction , and regeneration ."
reach
"The induction of additional pathways by CCR5, include the PI-3 ' K pathway and thereby PDK1 and serine/threonine kinase protein kinase B (AKT), which in turn induces cell survival, glycolysis, cell proliferation, growth and proliferation of progenitor and stem cells, immune cell differentiation and the release of eIF4E to promote cap dependent translation (XREF_FIG)."
reach
"The major findings of our study are that MPs PPARalpha +/+ : (i) increase EPC differentiation and EC marker expression, but not those of macrophage differentiation; (ii) enhances EPC differentiation that is mediated, at least in part, by PPARalpha-NF-kappaB and Akt pathways; (iii) modulate in vitro angiogenic related properties of ECs; and (iv) stimulate in vivo bone marrow derived cell associated neovascularization."
reach
"Considering GSK3beta was found to be an important downstream molecule of PI3-K-Akt in our previous studies [XREF_BIBR] and that of others [XREF_BIBR], we reasoned that the activation of PI3-K, Akt, and GSK3beta complex signaling pathways played important role in mediating the LPS induced lung fibroblast proliferation, differentiation and collagen secretion."
reach
"XREF_BIBR It has been established that Akt activation regulates the differentiation of CD8 + T cells into effector and memory T cells, where sustained Akt activation leads to terminal differentiation of effector CD8 + T cells, whereas inhibition of Akt in vivo increases the number of memory CD8 + T cells."
reach
"Overall, activating mutations of PI3K and AKT genes appear to cause profound disturbances of cellular proliferation, differentiation, and growth, reflecting the central role of these enzymes in development, and the widespread expression of the cognate genes in progenitors, neurons, and glia."
reach
"Moreover, it was found that the activation of FPRs increased the generation of reactive oxygen species (ROS) and phosphorylation of AKT in the NSCs, while N-acetylcysteine and LY294002 inhibited the FPRs stimulated increase in ROS generation and AKT phosphorylation, and blocked the FPRs stimulated neural differentiation into neurons."
reach
"In various cell types activation of Ras leads to activation of the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase 1/2 (ERK1/2), and protein kinase B (PKB)/Akt, which exert opposing effects on adipogenesis, with ERK1/2 inhibiting and PKB and Akt promoting terminal differentiation."
reach
"PIP3 thus functions as a second messenger initiating multiple signaling cascades, most notably facilitating the phosphorylation of AKT by PDK1 which subsequently leads to downstream survival and differentiation signals secondary to activation of the mechanistic target of rapamycin 1 (mTORC1) (40, 41) (Figure 1)."
reach
"XREF_BIBR and other studies have found that inhibition of AKT can limit in vitro MDSC differentiation, and XREF_BIBR discovered Treg is more susceptible to be inhibited after using AkT inhibitors, thus increasing CD8 + T cell number in tumor tissue to improve the control of tumor focus."
reach
"Notably, the PI3K/AKT signaling pathway is one of the most common pathways downstream of the receptor tyrosine kinases and is involved in the regulation of numerous cellular activities, including cell growth, migration, differentiation, apoptosis, and energy metabolism AKT is activated by the PI3K/AKT pathway and regulates tumor progression."
reach
"Targets in downstream or resistant pathways of particular interest in HER2-positive breast cancer include mTOR, PI3K, IGF-1R, Akt, HSP90, and VEGF that allow cell development, survival, and differentiation (Agus et al., 2005; Arteaga et al., 2012; Franklin et al., 2004; Nahta et al., 2006)."
reach
"In NSPCs, the elevating Akt activity in vitro increased cell survival and proliferation in cultured NSPCs derived from embryonic day 13 (E13) mouse cortex [XREF_BIBR], whereas Akt activation induced cell differentiation in cultured NSPCs derived from the medial ganglionic eminence (MGE) of E14 mouse [XREF_BIBR]."
reach
"Therefore, puberty for young male subjects might represent the main therapeutic window for mitigating bone loss.We found that long-term SD decreased the phosphorylation of PI3K and AKT and inhibited the PI3K/AKT pathway in skeletal tissue in a possible way of explaining inhibited osteogenic differentiation and bone development."
reach
"Since a previous study has shown that Akt mediated inhibition of FoxO1 induces PPARgamma and subsequent adipocyte differentiation XREF_BIBR and PI3K is in the upstream of Akt signaling pathway, we further found that the protein levels of FoxO1 were increased in VAT (P < 0.0001, XREF_FIG)."
reach
"For example, Wnt and beta-catenin and Akt signaling are inhibited by miRNAs to attenuate osteogenic differentiation of MSCs, Notch and NF-kappaB signaling are hindered to suppress the chondrogenic differentiation of MSCs, and the cell cycle is blocked by miRNA via targeting CDK6 to promote adipogenic differentiation of MSCs."
reach
"Interestingly, it has been shown that the PI3K and Akt signaling pathway plays a crucial role in many intracellular cascade events including tumor angiogenesis and tumor growth, and in particular, the PI3K and Akt pathway has been reported to drive the shear induced stem cell differentiation into ECs."
reach
"Whereas AKTi treated CD34 + cells showed enhanced B-lineage reconstitution compared with the control group, inhibition of AKT activity decreased T-cell and myeloid differentiation of CD34 + cells (XREF_FIG), which is consistent with the in vitro liquid culture experiment shown in XREF_FIG."
reach
"The functions of Akt in embryonic stem cells (ESCs) XREF_BIBR, adult stem cells XREF_BIBR and cancer stem cells (CSCs) XREF_BIBR have been investigated, but its precise role in the maintenance of stem cell homeostasis and the mechanism by which Akt modulates differentiation are yet to be clarified."
reach
"Complementary to our findings in P19 cells (Experiment 1), it was reported that active Akt can promote the differentiation of neuronal precursor cells into GABAergic neuron like cells XREF_BIBR and that phosphorylation of GABA A R via insulin induced Akt signalling can lead to an increase in the number of GABA receptors on the plasma membrane XREF_BIBR, thereby increasing inhibitory fast synaptic transmission in neurons."
reach
"The first cocktail contains compounds that activate Wnt, AMPK and PKB and AKT signaling to stimulate proliferation, survival and the insulin response, while the second cocktail includes small molecules that prevent apoptosis and promote hematopoietic differentiation (i.e. DITPA or VEGF inducer)."
reach
"Since recent studies pointed out the CSC subpopulation in tumours (including brain tumours) as the leading driver of malignant progression and relapse [XREF_BIBR] and previous results reported in this study clearly showed that PI3K and AKT downmodulation led to MDB cell growth inhibition, induction of cell death, and cellular differentiation, we examined the possible relationship between differentiation and cell death in MDB primary cells."
reach
"Taken together with findings that constitutively active Akt is sufficient to induce adipocyte differentiation in vitro in the absence of hormones and Akt null mice display severe defects in adipocyte development, an Akt/FOXO1/PPARgamma driven lipogenesis mechanism has solid experimental support [XREF_BIBR, XREF_BIBR]."
reach
"Activation of AKT pathway promotes cardiomyocyte differentiation through two different mechanisms, 1) through phosphorylation of GSK3beta to upregulate the expression levels of beta-catenin and Gata4; 2) through promotion of nuclear translocation of NF-kappaB by phosphorylating IKKbeta to inhibit cell apoptosis, which occurs due to increased Bcl2 expression."
reach
"XREF_BIBR Sustained Akt activation leads to terminal differentiation of effector CD8 + T cells, whereas inhibition of Akt in vivo increases the number of memory CD8 + T cells, XREF_BIBR and the downstream inhibition of mTOR augments the functional quality of cytotoxic CD8 + T-cell responses by prompting a CD8 memory phenotype."
reach
"Mechanistically, Pi retention is mediated by soluble carrier family 20 member 1 (SLC20A1) and sensed by diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) to enhance Akt activation, which then upregulates SLC20A1 to aggravate Pi retention and augments GATA2 activity to drive the expansion and megakaryocyte/myeloid-biased differentiation of HSCs."
reach
"Along with AMPK activation induced cell protective effects [XREF_BIBR], upon binding with Fstl1, Dip2a can upregulate AKT phosphorylation to protect cell from hypoxia and reoxygenation induced apoptosis and promote neovascularization by regulating endothelial cells ' migration and differentiation [XREF_BIBR]."
reach
"Overexpression of Pref-1 activates MAPK and AKT signaling, which induces the differentiation of human pancreatic ductal cells into beta like cells with increased insulin synthesis and secretion, and improves glucose homeostasis by accelerating pancreatic ductal and beta cell regeneration after injury in a pancreatectomized diabetic animal model [XREF_BIBR]."
reach
"92 Additionally, Vu et al. found that m A mediated by METTL3 promoted the translation of c‐MYC, BCL2 and PTEN mRNAs, and the PTEN transcript may encode a negative regulator of p‐AKT which was considered to promote differentiation and inhibit self‐renewal.93
Although METTL3 was previously thought to be down‐regulated in GSCs, the concept has become controversial."
reach
"Using CD8 + T cells from pdk1 K465E and K465E knockin mice, we found that decreased Akt activity inhibited the survival of T cells during the effector-to-memory cell transition and abolished their differentiation into C-X-C chemokine receptor 3 (CXCR3) lo CD43 lo effector like memory cells."
reach
"In addition, Studies have shown that PI3K-Akt signaling positively regulates Th17 differentiation via multiple mechanisms including the regulation of hypoxia inducible factor 1alpha (HIF-1 alpha) expression, Signal transducer and activator of transcription 3 (STAT3) phosphorylation, Gfi1 downregulation, and the nuclear translocation of RORgammat [XREF_BIBR - XREF_BIBR]."
reach
"Additional pathways induced by CCR5, include the PI-3 ' K pathway and thereby PDK1 and the serine/threonine kinase protein kinase B (AKT), which in turn induces cell survival, glycolysis, cell proliferation, growth and proliferation of progenitor and stem cells, immune cell differentiation and the release of eIF4E to promote cap dependent translation (XREF_FIG)."
reach
"Furthermore, PKB phosphorylation promotes venous differentiation at the expense of arteriogenesis.Hereditary hemorrhagic telangiectasia (HHT; or Osler–Weber–Rendu syndrome) and cerebral cavernous malformation (CCM) result from lowered and elevated signaling from the TGFβ/ BMP receptor complexes and sensitivity to messengers, respectively [210]."
| PMC
reach
"In conclusion, we determined that transient TNF suppresses the PI3K and AKT mediated melanoma SC differentiation and enlarges a GFP high melanosphere initiating CSC subpopulation that preserves the TNF instigated changes, reinforcing their post-TNF capacity to form tumor like melanospheres."
reach
"Akt signals downstream of PI3 kinase, and direct inhibition of either of these proteins causes differentiation of hESCs [XREF_BIBR, XREF_BIBR], as does inhibition of FKBP12-rapamycin-associated protein and mechanistic target of rapamycin (kinase), which signals downstream of Akt [XREF_BIBR]."