IndraLab
Statements
TNF activates cell differentiation. 1000 / 1886
1
|
13
1842
3
reach
"Receptor activator of nuclear factor-kappa B ligand (RANKL) is a member of the TNF ligand super family that binds to RANK receptors on osteoclast precursors to drive differentiation and activity (Graphical Abstract).94 Osteoprotegerin (OPG) is a soluble decoy receptor for RANKL and denosumab is an anti-RANKL inhibitor that inhibits osteoclastogenesis to promote bone accrual."
reach
"Many osteoclast-activating factors (IL-6, IL-1β, HGF and TNF-α) are released by the mutual interactions of tumour and bone marrow cells with a major involvement of RANKL, the decoy receptor OPG, and MIP-1α a.RANKL is a member of the TNF family that binds to RANK on osteoclast precursors and promotes the production and differentiation of osteoclasts."
reach
"In the present study, we showed that the combination of TNF and IL‐6, representative proinflammatory cytokines, induced the differentiation of TRAP‐positive multinucleated TNF and IL‐6–induced osteoclasts from human peripheral blood monocyte‐derived macrophages, and that these TNF and IL‐6–induced osteoclasts had the ability to absorb bone matrix."
reach
"Studies using human and rodent mesenchymal stem cells (MSCs) show that TNF contributes to osteogenic differentiation through the activation of NFkappaB, with downstream induction of bone morphogenic proteins (BMPs), osterix, RUNX2, osteocalcin (OCN), and alkaline phosphatase (AP)."
reach
"These findings suggest that the pro inflammatory cytokine TNF-alpha stimulates osteogenic differentiation of MSCs, an effect that can be blocked by the presence of anti-inflammatory agents like dexamethasone, with significant implications on the interplay between inflammation and tissue regeneration."
reach
"Among them, TNF-α can kill tumor cells or suppress their growth and enhance the phagocytosis, proliferation and differentiation of neutrophils; IL-1β can activate immune cells, assist in T-cell proliferation, participate in the production of antibodies and promote inflammation; IL-6 is the major factor that mediates inflammation, as it can activate immune cells to exert an immunoregulatory effect [27]."
reach
"In inflammatory response, epithelial cells are also important sources of leukotrienes for stimulating the recruitment of circulating leukocytes, generation of cytokines and ROS, increased TNF-alpha expression and induce activation, differentiation and proliferation of B cells, that are involved with immune response."
| PMC
reach
"In addition, studies have shown that TNF-α activates a nuclear factor-κB-dependent gene program to promote HSCs survival and differentiation (35), which provides a possible target for us to explore the senescence and apoptosis of HSCs and inhibit the NF-kB pathway that may inhibit liver fibrosis by inducing apoptosis of HSCs."
reach
"The small, yet significant, increases in TNFalpha and the increased osteoblastic response in young adult HRLF rats are similar to findings from other studies showing that low doses of TNF-alpha can stimulate osteoblast proliferation and osteogenic differentiation [XREF_BIBR - XREF_BIBR]."
reach
"In contrast, the highest dose of TNF-alpha had the opposite effect on MSCs; cell content remained fairly constant throughout the study (XREF_FIG), while mineralized matrix content increased monotonically (XREF_FIG; all three timepoints differ, p < 0.05), consistent with progression towards terminal osteogenic differentiation and with previous reports of human MSCs treated with human TNF-alpha in the absence of dexamethasone [XREF_BIBR, XREF_BIBR]."
reach
"Many studies have shown that TLR4 and LPS activated the MSC1 phenotype expressing pro-inflammatory mediators, while interferon-y (INF-y) and tumor necrosis factor α (TNF-α) activated TLR3 and promoted the differentiation towards MSC2 phenotype, which regulated peripheral immune cells (Naftali-Shani et al., 2017; Ferreira et al., 2018; Almeria et al., 2019; Ananthakrishnan et al., 2020)."
reach
"Many studies have shown that TLR4 and LPS activated the MSC1 phenotype expressing pro-inflammatory mediators, while interferon-y (INF-y) and tumor necrosis factor α (TNF-α) activated TLR3 and promoted the differentiation towards MSC2 phenotype, which regulated peripheral immune cells (Naftali-Shani et al., 2017; Ferreira et al., 2018; Almeria et al., 2019; Ananthakrishnan et al., 2020)."
reach
"Evidence has been provided, in fact, that tumor necrosis-factor-alpha (TNF-alpha) (via the p55 TNF-R1), IL-1beta, CD40 ligand (CD40L), and bacterial lipopolysaccaride (LPS) can promote DC differentiation in vitro, resulting in irreversible structural and functional changes associated with a mature DC phenotype, including downregulation of antigen uptake and processing capacity."
reach
"In contrast, pro-inflammatory M1 macrophages express enzymes such as nitric oxide synthase and cytokines such as TNF-α, IL-6, and IL-12, which promote inflammation, influence VIC and VEC properties and osteogenic differentiation potential, attract monocytes to the valve, and further propagate the inflammation [51]."
reach
"These findings were supported later in vitro studies in which the combined subinhibitory concentrations of MIF, TNF-alpha and IFN-gamma acted synergistically to inhibit erythroid differentiation and hemoglobin production by antagonizing the pattern of mitogen activated protein (MAP) kinase phosphorylation that normally occurs during erythroid progenitor differentiation."
reach
"TNF liked ligand 1A (TL1A) is another TNF family cytokine that acts through its receptor, death receptor 3 (DR3), to promote the differentiation of Th9 cells via an IL-2-STAT5-dependent mechanism, but not the lL-4-STAT-6 signaling axis involved in OX40 induced Th9 cell differentiation."
reach
"TNF liked ligand 1A (TL1A) is another TNF family cytokine that acts through its receptor, death receptor 3 (DR3), to promote the differentiation of Th9 cells via an IL-2-STAT5-dependent mechanism, but not the lL-4-STAT-6 signaling axis involved in OX40 induced Th9 cell differentiation."
reach
"TNF-α and transforming growth factor (TGF-1) can induce the
proliferation, differentiation, and collagen production of fibroblasts
and promote the destruction of the basement membrane and the migration
of fibroblasts by activating proteolytic enzymes, thus participating
in the pathogenesis of ILD."
reach
"In the current pathophysiological model of psoriasis, pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, activate myeloid dendritic cells, which subsequently release IL-12 and IL-23.24 IL-12 induces differentiation of type 1 helper T (Th1) cells, which secrete pro-inflammatory cytokines TNF-α and IFN-γ, whereas IL-23 induces differentiation of type 17 helper T (Th17) cells, which secrete pro-inflammatory cytokines IL-17A, IL-17F, and IL-22."
reach
"To explore the possibility that TNF stimulates keratinocyte differentiation at least in part by regulating 1,25-(OH) 2D production we examined the effect of TNF on both 1,25-(OH) 2D production and differentiation (transglutaminase activity, cornified envelope formation) at different stages of differentiation."
reach
"As mentioned above, TNF-alpha and IFN-gamma secreted by the NK cells synergistically augmented differentiation of cells resulting in an increase in MHC class I, CD54 and B7H1 and their resistance to NK cell mediated cytotoxicity and decrease in cytokine and chemokine secretion by the NK cells cultured with differentiated cells [XREF_BIBR]."
reach
"An analysis performed on rectal biopsy samples highlighted a methylation profile in the Thyroid Hormone Receptor Associated Protein (THRAP2), Forssman Glycosyltransferase 1 (GBGT1), Tumor Necrosis Factor Ligand (TNFSF), and Fucosyltransferase 7 (FUT7) that allows the differentiation of IBD patients from healthy controls [103]."
reach
"Therefore, even though TNF-α stimulated MCs can increase Treg differentiation, the harmful Th2 effects may outweigh any protective functions.Chymase inhibitors were found to be effective in reducing inflammation and led to a significant increase in the expression of immune-tolerance-related cytokines (IL-10, TGF-β1, IL-17A), FoxP3, and the amount of Tregs [121]."
reach
"However, whether Th17 cells promote the stability and proliferation of Treg cells in other ways remains to be further verified.In addition to cytokines produced by Th17 cells, such as TNF, which promote the differentiation and function of Treg cells, the components of Th17 differentiation mechanism also promote the function of Treg cells."
reach
"We found that H19 was downregulated in both atopic dermatitis (Fold Change FC =0.31; FDR = 3.26x10
) and psoriasis (Fold Change FC = 0.05; FDR = 3.34x10
) lesional skin, and it was also depleted in the IFN and IL17/TNF stimulated keratinocytes, further supporting our understanding of aberrant differentiation of keratinocytes in many skin diseases, such as psoriasis and atopic dermatitis (Li et al., 2017; Tang et al., 2020)."
reach
"Interactions of TNF-α with its receptor activate signaling pathways for cell survival, death and differentiation that control immune function and disease, and various receptors pairs of ligands within TNF family molecules expressed by immune cells that play important roles in T cell Immunity[26]."
reach
"The present study demonstrates that Oroxylin A, a natural compound isolated from Scutellariae radix, sensitizes leukemia cells to TNFalpha and markedly enhances TNFalpha induced growth inhibition and differentiation of AML cell including human leukemia cell lines and primary AML cells."
reach
"T lymphocytes receive dendritic cells and other antigen-presenting cells to produce IL-23, TNF-α induces differentiation and proliferation of CD4+ T lymphocytes (Th17 cells), and mature Th17 cells can secrete various cytokines such as IL-17, IL-21, IL-22, etc., which keratinocyte overproliferation or inflammation of synovial cells."
reach
"Because M1 macrophages secrete large amounts of TNFalpha and IL-1beta that contribute to the differentiation of T H 17 cells, they are also believed to be important drivers of chronic inflammatory and autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, atherosclerosis, pulmonary fibrosis, and Crohn 's disease [XREF_BIBR - XREF_BIBR] (see Section 3.3)."
reach
"In this co-culture system, it is likely that osteoclast differentiation was upregulated by TNF-alpha by both direct and indirect effects, including induced stromal cell and osteoblast production of RANKL, as well as increased sensitivity of osteoclast precursors to RANKL stimulation."
reach
"Such molecules include members of the osteoprotegerin and receptor for activation of NF-kB ligand (RANKL)/RANK pathway, where RANKL is a tumor necrosis factor family member secreted by osteoblasts with a role to trigger the differentiation of mesenchymal stromal cells to osteoclasts and speed up the complementary bone degradation processes."
reach
"Tumor differentiation was largely mediated by both IFN-gamma and TNF-alpha secreted by activated NK cells, since the addition of the combination of anti-TNF-alpha and anti-IFN-gamma retained the OSCSCs, MP2 pancreatic XREF_BIBR and A549 lung cancer cells in a non differentiated stage as assessed by susceptibility to NK cell mediated lysis and decreased B7H1 and MHC class I expression."
reach
"The conjunct of RANKL and RANK recruits TNF receptor associated factors (TRAFs), typically TRAF6, which activates multiple downstream signaling pathways, mainly NF-kappaB, MAPKs, and AKT, and thereby initiates osteoclast differentiation and bone resorption by inducing transcription and expression of osteoclast specific genes, such as tartrate resistant acid phosphatase (TRAP), cathepsin K, matrix metalloproteinase 9 (MMP-9), and C-Src."
reach
"A cytokine screen conducted by Edgar et al. revealed that IL-3 and TNFα significantly enhance the yield of CD5 CD7 T cell progenitors, with IL-3 promoting the proliferation of myeloid-biased CD34 HSPCs and TNFα inducing T-lineage differentiation by modulating NOTCH target genes, leading to a substantial expansion of early T cell progenitors [93]."
reach
"Because integrin alpha 5 beta 1 modulated both monocyte adhesion to fibronectin and also TNFalpha induced endothelial differentiation on that substrate, we designed in vivo experiments to assess the effects of blocking alpha 5 beta 1 on myeloid to endothelial differentiation (i.e. generation of vascular leukocytes) in vivo."
reach
"In contrast, mouse TNFalpha failed to induce TNF-Rp55-deficient mice derived Lin-c-kit+ HPCs to generate DCs with characteristic morphology, immunophenotype, and accessory function for T cells under the same culture conditions, suggesting a crucial role of TNF-Rp55 in TNFalpha mediated DC differentiation from HPCs."
reach
"Tumour necrosis factor-alpha (TNF-alpha) induces differentiation on human promyelocytic leukemia cells (HL-60) as assessed by growth inhibition accompanied by reduction of c-myc levels, and expression of surface colony stimulating factor-1 (CSF-1) receptors reported as molecular markers for acute myeloid leukemia (AML)."
reach
"Tumor necrosis factor-alpha (TNF-alpha), a potent cytokine involved in the regulation of osteoclast activity, promotes bone resorption via a primary effect on osteoblasts; however, it remains unclear whether TNF-alpha can also directly induce the differentiation of osteoclast progenitors into mature osteoclasts."
reach
"Mithramycin is an antineoplastic agent produced by Streptomyces plicatus which behaves as DNA/RNA polymerase inhibitor, DNA-binding transcriptional inhibitor and antibiotic and has been observed to facilitate tumor necrosis factor (TNF)-α activity and Fas-ligand-induced, which is known to induce malignant cell reprogramming, differentiation, and senescence [134,135]."
reach
"TNF-α mainly enhances the immune response by enhancing macrophage activation and antigen presentation, inhibits osteoblast activity at specific differentiation stages, and stimulates the proliferation and differentiation of osteoclasts, thereby regulating bone reconstruction [45]."
reach
"Moreover, this study found that PADI4 may contribute to cancer development and progression by increasing the expression of CXCR2, KRT14 and TNF-alpha, which activate pro inflammatory processes, angiogenesis, cell migration, cell proliferation and cell differentiation in tumor tissues."
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR Growth differentiation factor-15 expression is induced by TNF-alpha, interleukins, P53, Egr-1, and macrophage colony stimulating factor, XREF_BIBR, XREF_BIBR, XREF_BIBR XREF_BIBR - XREF_BIBR with the protein widely being considered a biomarker for various diseases."
reach
"IL-6, IL-8, and tumor necrosis factor stimulate the production of IFN- γ and further IL-8 by T cells to strengthen the immune response; IL-8 recruits neutrophils into this region, which release more cytokines, and the epithelial response to environmental stimuli leads to the activation of dendritic cells, thereby inducing the differentiation of Th1 and Th17 cells [66]."
reach
"The results indicated that TNF-alpha did not effectively induce osteoclast differentiation from osteoclast progenitor cells derived from these mice into mature multinucleated osteoclasts, although c-jun N-terminal kinase (JNK) and TNF-alpha activation was observed in osteoclast progenitor cells."
reach
"These data collectively indicate that Def6 regulated endogenous IFN-beta production contributes to the control of osteoclast differentiation by RANKL or TNF-alpha and also indicate that Def6 suppresses c-Fos and NFATc1 and Blimp1 axis at least partially via regulating an endogenous IFN-beta mediated inhibitory loop during osteoclastogenesis."
reach
"Bacteria and their by-products can induce the release of pro inflammatory cytokines, such as macrophage chemoattractant protein-1 (MCP-1), tumour necrosis factor-alpha (TNF-alpha), interleukins (ILs) and prostaglandin E2, which directly or indirectly stimulate osteoclast differentiation."
reach
"Moreover, vitamin D might exert immunomodulatory effects by inhibiting the expression of IL-6, IL-8, TNF-alpha, and TNF-gamma, modulate dendritic cell maturation, differentiation, and activation as well as induce the inhibition of antigen presentation XREF_BIBR, thereby dampen the autoimmune pathway incriminated in the pathogenesis of vitiligo."
reach
"Thus, c-Myc protein is critically implicated in the decision of the fate of a cell to undergo survival or death.To understand the mechanisms by which activation of PKC prevents TNF-a- induced apoptosis, we examined the effect of PMA pretreatment on c-Myc protein expression in HL-60 cells and found that prior activation of PKC prevented onset of apoptosis via rapid up-regulation of c-Myc protein and resulted in enhancement of TNFa induced differentiation of HL-60 cells."
reach
"Furthermore, stem cell factor (Pan et al., 2013), tumor necrosis factor-a (TNF-α) (Shi et al., 2017), interferon-γ (IFN-γ) (He et al., 2017b), and BMP (Kim et al., 2010) have also been reported to promote dental pulp regeneration by increasing odontogenic MSCs migration and differentiation."
reach
"In a phase I clinical trial, plasma concentration of B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) in refractory RA patients, cytokines from a large family of TNF promoting differentiation and survival of B cells, significantly decreased after the MSCs transplantation."
reach
"In addition, macrophages produce cytokines and growth factors, such as IL-1, IL-6, TNF-alpha, TGFalpha, PDGF, VEGF and EGF, that stimulate proliferation, migration or differentiation of fibroblasts, keratinocytes and endothelial cells, and ultimately stimulate ECM deposition, re-epithelialization and neovascularization."
reach
"Alternative cytokines and signaling molecules such as IL-25, IL-1, TSLP, Jagged-2, calcitonin gene related peptide and the TNF family member OX40 ligand (OX40L) have been proposed to enhance Th9 differentiation and/or T-cell production of IL-9, while cyclooxygenase-2-derived prostaglandins, programmed cell death ligand 2, and 1,25-dihidroxyvitamin D 3 inhibit Th9 polarization."
reach
"XREF_BIBR In turn, IL-23 sustains Th17 proliferation, hence primarily increasing levels of IL-17 and IL-22 produced by these activated Th17 cells (It has been suggested that Th0 differentiation into Th17 is originally initiated by IL-6 and TGF-beta, and then supported by IL-23 and TNF-alpha)."
reach
"First thought that IL-23 was the inducing cytokine for Th17 cells, three groups simultaneously discovered that TGF-β and IL-6 induced Th17 differentiation (28–30), while IL-1β and tumor necrosis factor (TNF)-α can potentiate Th17 differentiation in presence of IL-6 and transforming growth factor beta TGF-β (31–33)."
reach
"The regulatory effect of YAP on MDSCs is reflected in two aspects: First, directly transcribing chemokine CXCL5 to promote the recruitment of MDSCs in prostate tumor cells (72); Second, promoting the expression of IL-6, CSF1-3, TNF-α, IL-3, CXCL1/2, and CCL2 to promote the recruitment and systematic differentiation of MDSCs in the Kras: p53-mutant PDAC model (71)."
reach
"GSE reduced the secretion of TNF-α, IL-1 β and IL-6 in bone marrow-derived macrophages stimulated by lipopolysaccharide (P<0.01), inhibited the secretion of TNF-α, IL-1 β, IL-6, IL-12, IL-17 and IFN-γ in spleen cells of EAE mice immunized for 9 days (P<0.05 or P<0.01), and reduced the differentiation of Th1 and Th17 mediated by CD3 and CD28 factors (P<0.01)."
reach
"43 An iTRAQ proteomics study revealed that the TNF signaling pathway promoted the osteogenic differentiation of LF cells by activating Osx expression.12 Besides, numerous researches demonstrated that the TNF signaling enhanced the osteogenic differentiation ability of periodontal ligament stem cells (PDLSCs) in periodontitis.44–46 However, no studies were conducted to uncover the role of the toll-like receptor signaling pathway in OLF."
reach
"Firstly, TNF-α promotes the differentiation of CD4 T helper (Th) cells 1796 so that the content of Th 17 cells in the bone marrow of OVX mice gradually increases.97 IL-17 secreted by Th17 cells upregulates RANK on osteoclast progenitors, increasing their sensitivity to RANKL stimulation.98 Furthermore, blocking IL-17 signaling prevented OVX-induced bone loss,99 suggesting that cytokines secreted by T cells play an important role in the pathological process of PMOP."
reach
"96 In contrast, Lam et al. 97 have shown that although TNFalpha alone fails to induce differentiation of murine osteoclast precursors, priming with RANKL (with a concentration that is insufficient to induce osteoclastogenesis by itself) dramatically enhances TNFalpha induced osteoclast differentiation."
reach
"Several mechanisms of action have been proposed to account for these effects : TNF directly inhibits osteoblast differentiation; TNF augments osteoclast formation by inducing stromal cells to increase expression of RANKL and macrophage colony stimulating factor (M-CSF) and decrease that of osteoprotegerin (OPG); and TNF serves to synergize with pathways downstream of RANK to directly increase osteoclast differentiation."
reach
"TNF-α stimulates the differentiation of osteoclasts through nuclear factor kappa-B (NF-κB) and upregulates several target genes such as RANK and on the other hand suppresses differentiation of osteoblasts by inhibiting osteogenic factors such as runt-related transcription factor 2 (RUNX2) [47, 48]."
reach
"In conclusion, we have shown that a PMT induced activation of G proteins in primary osteocytes and in the osteocyte like cell line MLO-Y4 leads to an elevated production and secretion of the osteoclastogenic cytokines RANKL and TNF-alpha, which efficiently contributes in an indirect manner to the differentiation of osteoclasts."
reach
"In addition, TNFα can induce anemia in patients with MM by directly inhibiting the formation and differentiation of red blood cells, reducing sensitivity to erythropoietin (EPO), and promoting IL-6 secretion by myeloma cells.IL1β is a pro-inflammatory cytokine11 that is primarily secreted by monocytes and macrophages and encoded by the IL1B gene."
reach
"Our findings suggest that TNF-alpha, BAFF and APRIL, and BCMA might contribute to the pathogenesis of BD possibly through augmentation of both innate and adaptive immune responses as well as by collaborating with other inflammatory cytokines to promote the activation and differentiation of effecter immune cells involved in the pathogenesis of BD."
reach
"Some essential factors associated with pyroptosis activator of nuclear factor-κB ligand (RANKL), macrophage colony-stimulating factor (M-CSF), TNF-α, and IL family, stimulate further differentiation and fusion of OCPs into multinucleated osteoclasts, leading to bone loss [64, 65] (Table 1)."
reach
"The random forests analyses, without and with adjustment for differences in demography, comorbidities and severity of disease, identified six biomarkers (adrenomedullin, TNF receptor-1, adipocyte fatty acid binding protein-4, TNF related apoptosis inducing ligand receptor 2, growth differentiation factor-15 and TNF receptor-2) to be strongly associated with CKD."
reach
"Osteoblasts and stromal cells control bone degradation by expressing the Macrophage-Colony Stimulating Factor (M-CSF) required for the proliferation of osteoclast precursors and the Receptor for Activation of NF-kB Ligand (RANKL), a TNF family member triggering their differentiation XREF_BIBR, XREF_BIBR - XREF_BIBR."
reach
"Complementary to this evidence, studies in mice (105) and in rabbits (106) demonstrate that the adipocyte-promoted myeloid expansion and IL1β production inhibit B lymphopoiesis.Also, tumor necrosis factor alpha (TNFα) has been shown to be upregulated in HSCs upon aging, promoting myeloid differentiation skewing, HSC survival, and changes in the immunomodulatory properties through the activation of a nuclear factor-κB (NF-κB)-dependent gene program (94)."
reach
"Statin treatment did not alter serum levels of GM-CSF, TNF-alpha, and VEGF, supporting the hypothesis that statin treatment stimulates the differentiation of endothelial precursor cells into EPCs, suggesting that statins directly enhance the EPC migration ability in patients with CAD."
reach
"Here, we determined thatCD46 +/+ mice produce large numbers of M1 type macrophages with enhanced surface expression of MHC II and production of pro inflammatory mediators such as IL-6, TNF, IL-12, and IL-1beta In the presence of M-CSF or GM-CSF, CD46 signaling enhances monocyte-macrophage differentiation."
reach
"These results together with the increased expression of CD80, CD86, IL2RA and the cytokines/chemokines TNF-α, CXCL10, IL1-β and IL12A, known markers of M1 polarization [[37], [38], [39]], suggest that RA NPs induced the differentiation of MLL-AF9 cells towards an M1-like phenotype (Fig. 3C)."
reach
"To test this hypothesis, dendritic cells (DC) were generated in vitro from isolated monocytes, and changes in content, localization, and secretion of CyC and cathepsins S, L, and H (CatS, -L, and -H, repsectively) were followed in response to interleukin-4, enabling monocyte differentiation, and to tumor necrosis factor alpha (TNF-alpha), enabling DC maturation."
reach
"Furthermore, individual therapeutic modalities frequently have discrepant effects on different biologic functions; for instance, steroid effects on bone erosion are both positive (e.g., the potentiation of RANKL induced OC differentiation) and negative (e.g., the inhibition of TNF -- induced OC differentiation; Fig. 4)."
reach
"Briefly, M1 macrophage differentiation was induced by the addition of tumor necrosis factor (TNF)α (10 ng/ml) and M2 macrophage differentiation was induced by the addition of a low concentration of recombinant human interleukin (IL)-4 (15 ng/ml) (Promocell, Heidelberg, Germany) for 6 days."
reach
"TNF enhances OC activity by directly promoting OC differentiation of bone marrow macrophages exposed to permissive levels of RANK-ligand (RANKL), XREF_BIBR by stimulating RANKL expression by T and B lymphocytes, XREF_BIBR by promoting stromal RANKL production by osteoblasts (OB), and by enhancing RANK and IL-1 expression by myeloid OC precursors."
reach
"High lactate concentrations with low pH can decrease the production of tumor necrosis factor-alpha (TNF-α) and interleukin-1β (IL-1β) by macrophages/monocytes.18 Moreover, studies have reported that lactic acid may inhibit the secretion of TNF by interfering with the glycolysis of human monocytes and suppress the differentiation of monocytes into dendritic cells, as well as the activation of T cells.19–22 For a more in-depth exploration of the immunomodulatory mechanisms of lactic acid, Peter K et al conducted a comprehensive analysis of its impact on gene expression during monocyte activation."
reach
"In addition to RANKL, recent studies have demonstrated there are several TNF family molecules which promote osteoclast differentiation, including TNF XREF_BIBR, decoy receptor 3 (DcR3) XREF_BIBR, FasL XREF_BIBR and TRAIL XREF_BIBR; indicating that activated T cells and inflammatory response can remodel bone homeostasis via these effector molecules."
reach
"This was supported by experiments in which the authors demonstrate that RANKL and TNF successfully induced osteoclastogenic differentiation of osteoclast progenitor cells derived from NF-kappaB p50 and p52 deficient mice which were reconstituted with c-Fos and NFATc1 [XREF_BIBR, XREF_BIBR]."
reach
"In the initiation phase of psoriasis, various triggers can cause the activation of keratinocytes and the release of nucleic acids and antimicrobial peptides, which causes the activation of dendritic cells producing mainly TNF-alpha, IL-12, and IL-23, which initiate the differentiation of T cells into Th1, Th22, and Th17 subsets."
reach
"M1 macrophages secrete cytokines such as IL‐1, IL‐6, IL‐23, and TNF‐α, promote the differentiation of T cells into Th1 and Th17, stimulate osteoclasts and synovial cells, and attract monocytes and neutrophils to specific sites (Tardito et al. 2019; Hoseinzadeh et al. 2023; Hosseini et al. 2024)."
reach
"Thus, we demonstrated that the PA stimulated increase in IL-18 production in the IBC-NST biopsy samples may inhibit or block MDTC-to-HDTC differentiation after exposure to PAs; this differentiation may be mediated by other cytokines (IL-6 and/or IL-1beta, IL-1Ra, TNF-alpha and GM-CSF)."
reach
"In this regard, we have recently reported that tumor necrosis factor-alpha (TNF) modulates in vitro differentiation of cardiac stem cells in a TNF receptor dependent manner; 15 specific pro inflammatory signaling pathways may have analogous effects in MSCs that in turn impact reparative efficacy."
reach
"Intriguingly, iNOS and TNFα markers were also increased in neurons 60 min after exposure to Sema 3A media, indicating that a very short inflammatory insult, during the very early stages of neuronal development may promote neuroinflammatory pathways and affect differentiation and connectivity."
reach
"25 Mouse recombinant IL-6 (50ngml -1; eBioscience; Santa Clara, CA, USA), human recombinant TGF-beta1 (2ngml -1; eBioscience), mouse recombinant IL-1beta (2ngml -1; eBioscience), mouse recombinant TNFalpha (1ngml -1; eBioscience), anti-IFNgamma Ab (XMG1.2; 10mugml -1) and anti-IL4 Ab (11B11; 5mugml -1) were added to the culture medium to induce Th17 cell differentiation."
reach
"The levels of the proinflammatory cytokines TNF-alpha and IL-1beta, which can enhance inflammation or induce further effector T cell differentiation, were significantly lower in the H.pylori-infected IL-21 -/- mice than in their H.pylori-infected wild-type littermates both at the protein (XREF_SUPPLEMENTARY) and RNA levels (XREF_SUPPLEMENTARY)."
reach
"However, our previous in vitro study demonstrated that preconditioning of murine BM-MSCs using TNFalpha alone or a combination TNFalpha and IFNgamma did not promote osteogenesis; however, a combination of TNFalpha and LPS enhanced osteogenic differentiation including ALP activity and matrix mineralization."
reach
"Interestingly, studies have also shown that the cocktail of TNF-alpha, IL-1beta, and IFN-gamma can direct the differentiation of pancreatic ductal cells towards the endocrine lineage and hence this may be important in the setting of regenerating the pancreas following its destruction in the setting of either diabetes or pancreatitis."
reach
"Haloperidol did not affect the release of proinflammatory cytokines IL-6, IL-8 or TNF-a in LPS stimulated macrophages.Effect of APDs on the production of potent Th1 and Th2 cytokine of human macrophagesThe cytokines IL-12 and IL-10 are prominent in Th1 and Th2 cell differentiation."
reach
"To determine if BRG1 generally associates with NF-kappaB under conditions that lead to its activation or the association occurs only under certain conditions, such as during Schwann cell differentiation, HEK 293 cells were treated with TNFalpha, which stimulates NF-kappaB binding."
reach
"Together, these results indicated that PI3K activation can rescue the mammary epithelial cell population shift induced by CL and infliximab treatment.Taken together, these results suggested that TNF-α modulates MaSC activity and mammary epithelial cell differentiation via PI3K signaling and regulates cell division through Cdk1/Cyclin B1 axis."
reach
"Collectively, the results in XREF_FIG and XREF_FIG indicate that C5a acts on macrophages in the joint and other tissues to provoke their production of IL-1, IL-6, TNF, and IL-23, and together with tissue TGF-beta, promotes the differentiation and expansion of self-reactive T cells into Th17 cells."
reach
"The microglial myeloid differentiation primary response 88 (MyD88) and the p38 mitogen activated protein kinase (MAPK) signaling pathways are also involved and drive the release of neurotoxins, in a process initiated by the pro-inflammatory cytokine TNF, contributing to the damage of neurons (Michaud et al., 2011; Wang et al., 2015; Schnöder et al., 2016)."
reach
"Taken together, these recent studies provided deeper mechanistic understanding of the dynamics of synovial fibroblast subpopulations during pathogenesis of arthritis, paving the way to the discovery of mesenchymal cell-targeted therapeutics beyond anti-TNFs.Along with interleukin-6 (IL-6), TNF-α stimulates synovial fibroblasts to produce receptor activator of NF-κB ligand (RANKL) promoting osteoclasts’ differentiation and activation [33]."
reach
"TNFalpha is known to directly induce bone resorption by activating mature osteoclasts and stimulating the proliferation and differentiation of osteoclast precursors or indirectly by inducing the expression of osteoclastogenic factors in stromal cells or osteoblasts [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
reach
"On the basis of studies using several kinds of the arthritis mouse model, it has been shown that IL-17 plays a central role in the development of RA through activating synoviocytes, fibroblasts, endothelial cells, and macrophages to induce TNFalpha, which subsequently induces inflammation and osteoclast differentiation in multiple synovial joints [14,22]."
reach
"To reveal the gene expression responses in the cells prepared for MSC transdifferentiation and transplantation, the following treatments were applied: (I) IL-1β to suppress inflammation in adipose tissue, (II) TNF-α to promote cell proliferation and differentiation while suppressing apoptosis, (III) PolyI:C used for priming or boosting therapy to unleash lymphocytes and other factors of the targeted therapeutic pathway, (IV) LPS to boost the immune plasticity of the cells, and (V) IFN-γ to improve therapeutic effectiveness."
reach
"This indicates that in this disease model two mechanisms are essentially involved in inflammatory bone destruction : (a) Neighboring stromal cells need to provide excess amounts of proinflammatory factors, such as TNF, which induce osteoclast differentiation from mononuclear precursors; and (b) Osteoclastogenesis must overcome CD44 mediated cell-matrix interactions, which prevent tissue remodeling and damage."
reach
"Although TNFalpha was undetectable in any coculture conditions, TNFalpha has been reported to increase preadipocyte proliferation and block differentiation, and consistent with these reports, we observed that 100 ng/ml TNFalpha increased preadipocyte proliferation and potently blocked differentiation (XREF_FIG)."
reach
"Gene expression of vWF, CD31, VE-cadherin, Flk-1, and Flt-1 was significantly attenuated by Etanercept in the cells by 31.0 +/-6.5%, 74.0 +/-6.2%, 79.2 +/-2.9%, 79.0 +/-2.8%, and 48.7 +/-7.6% (n = 3, p < 0.05), respectively (XREF_FIG), suggesting that TACE and TNF-alpha signaling mediate the endothelial differentiation of MSCs in direct co-culture condition."
reach
"After binding to the receptors, TNF initiates cell proliferation, differentiation and pro inflammatory signalling [via activation of the nuclear factor-kappaB (NF-kappaB) and mitogen activated protein kinases (MAPK) pathways].9 Additionally, TNF signalling induces apoptosis of intestinal epithelial cells as well as inducing changes in the epithelial expression of tight junction proteins (via caspase-8 activation).9 Hence, increased TNF-alpha expression might decrease the mucosal barrier function.9 Biologics are bioengineered therapeutic agents targeting a gene or a protein."
reach
"Activation of B lymphocytes results in the secretion of various cytokines, including tumour necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), interleukin-1 (IL-1) and interleukin-6 (IL-6), which primarily target the orbital adipocyte, inducing its differentiation into a mature adipocyte and the synthesis of glycosaminoglycans (GAGs), particularly hyaluronan (HA)."
reach
"Costimulatory signals initiated by the interaction between the tumor necrosis factor (TNF) ligand and cognate TNF receptor (TNFR) superfamilies promote clonal expansion, differentiation, and survival of antigen primed CD4 + and CD8 + T cells and have a pivotal role in T-cell-mediated adaptive immunity and diseases."
reach
"Whereas physiological levels of Tnf are transiently up-regulated during myoblast regenerative responses to injury and stimulate differentiation, sustained high levels of TNF are associated with chronic inflammatory diseases and especially with muscle pathology associated with impairment of differentiation and muscle wasting."
reach
"At advanced stages of COVID-19, intense activation of the NLRP3 inflammasome and TLR2-MyD88-NF-kappaB mediated pathways most likely create a cytokine environment enriched in IL-1beta, IL-23, IL-6, and TNF, which would further elicit Th17 differentiation and GM-CSF production by gammadeltaT17, Th17, and CD8 T cells (XREF_FIG)."
reach
"TNF-alpha is released by activated monocytes, macrophages and T lymphocytes and contributes to both innate and adaptive immune responses, regulating growth, differentiation, survival and physiological function of a variety of different cells and further production of other cytokines, inflammatory mediators and enzymes XREF_BIBR - XREF_BIBR."
reach
"Exploration of immune cell diversity and network interactions suggested that M1 macrophages, neutrophils and NK cells may stimulate cell cycling and proliferation in MSCs, possibly through Sell‐, Tnf‐ and Thbs1‐mediated activation of STAT signaling, whereas Lgals9 expressed by M2 macrophages and Ifng expressed by CD4 and/or CD8 T cells might promote osteochondral differentiation."
reach
"Endogenous TNFalpha released in co-cultures of CD34+ and allogeneic T cells was then demonstrated to mediate the rapid differentiation of a subset of CD34+ cells into monocytic and dendritic cells, whereas co-transplantation of CD34+ and T cells into NOD and SCID mice resulted in increased differentiation of mature dendritic cells."
reach
"Polymethylmethacrylate (PMMA), polyethylene and metal debris enhance local secretion of proinflammatory factors including interleukin- 1, interleukin-6, TNF and prostaglandin E2 [10,12,15,16] which mediate differentiation of osteoclast precursor cells into bone resorbing mature osteoclasts."
reach
"XREF_BIBR, XREF_BIBR VEGFA, another autocrine signal, has been described to contribute to the immobilisation of progenitor cells and the maintenance of stem cells, XREF_BIBR, XREF_BIBR, XREF_BIBR while TNFalpha, a well-known proinflammatory cytokine, can promote osteogenic differentiation of mesenchymal stem cells."