IndraLab

Statements

USP26 binds CBX4 and CBX6. 5 / 5
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"Since the undifferentiated ESCs expressed CBX7 but no USP26, endogenous interactions between USP26 and CBX4 or CBX6, but not CBX7, were only observed in differentiating ESCs (Fig.  xref )."
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"Taken together, these results suggest that USP26 physically binds to components of the PRC1 complex, including RING1A, CBX4, and CBX6, and the interaction between USP26 and CBX4 or CBX6 is independent of the presence of RING1A."
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"IP experiments showed binding of FLAG-USP26 and CBX4 or CBX6 in RING1A KO 293T cells (Fig.  xref ), suggesting that USP26 and CBX4 or CBX6 interactions are RING1A-independent."
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"However, when USP26 was expressed with either Cbx4 or CBX6, significantly decreased promoter activities of Sox2, Nanog , and Cbx7 were observed (Supplementary Fig.  xref ), suggesting that USP26 interacts with Cbx4 or Cbx6 alone or both in Cbx7 promoter for CBX7 suppression."
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"However, the interaction of USP26 with CBX4 and CBX6 was independent of RING1A. In differentiated cells, USP26 removed K48-linked Ub chains from CBX4 and CBX6, thus stabilizing the proteins and preventing their degradation."
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