IndraLab

Statements

USP7 inhibits Proteasome. 3 / 5
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"Because USP7 broadly rescued substrate degradation in UbVS/ubiquitin-treated extract ( xref , xref ) and has been reported to be associated with the proteasome ( xref ; xref ), USP7 might inhibit the proteasome independent of its catalytic activity, as is known for USP14 ( xref )."
33417828
eidos
"The nuclear Yki protein is destabilized by proteasome , which is attenuated by Usp7 In this study , we found that usp7 steadily expressed throughout different developmental stages of Drosophila in a Hpo pathway-independent manner , indicating that Usp7 is likely a constitutive regulator of Yki without context specificity ."
30679505
reach
"After in-depth study, we found that USP7 could inhibit the proteasome pathway mediated degradation of Ki-67 protein by its deubiquitination function, and thus stabilize Ki-67 protein in NSCLC cells."
27590858