IndraLab

Statements

Catalytically active CASP8 inhibits CYLD. 2 / 2
2 |
bel
"Therefore, removal of CYLD-WT by CASPASE 8 prolongs the ubiquitination state of RIPK1 and maintains RIPK1 in a pro-survival complex with NEMO. In contrast, the resistance of CYLD-D215A to proteolytic cleavage by CASPASE 8 resulted in less ubiquitination of RIPK1 (Figure 5), which enhanced RIPK1 interaction with the necrosome to initiate death (Figure 4). These observations demonstrate that CASPASE 8 cleavage of CYLD functions as a pro-survival event by preventing CYLD from deubiquitinating RIPK1"
22037414
bel
"Therefore, removal of CYLD-WT by CASPASE 8 prolongs the ubiquitination state of RIPK1 and maintains RIPK1 in a pro-survival complex with NEMO. In contrast, the resistance of CYLD-D215A to proteolytic cleavage by CASPASE 8 resulted in less ubiquitination of RIPK1 (Figure 5), which enhanced RIPK1 interaction with the necrosome to initiate death (Figure 4). These observations demonstrate that CASPASE 8 cleavage of CYLD functions as a pro-survival event by preventing CYLD from deubiquitinating RIPK1"