IndraLab

Statements

UCHL1 activates UCHL1. 7 / 7
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"Moreover, overexpression of UCHL1 delays AD progression in mouse models, and UCHL1 gene therapy, to overexpress UCHL1, in the brain potentially could be a promising disease modifying strategy for AD therapeutics."
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"This is due to very high levels of UCH-L1 which lead to an increase in the UCH-L1 substrate and also more damaged UCH-L1."
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"The loss of Cav-1 and compact myelin proteins following hyperglycemia and NRG treatment was not due to neuronal loss, since the axons remained intact and there was no loss of PGP 9.5, an axonal marker protein."
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"Interestingly, UCHL1 expression triggered the accumulation of free monoubiquitin similarly to UCHL1 (Fig. 8e, compare lane 4 with lane 2)."
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"Furthermore, there is frequent overexpression of PGP9.5 in NSCLC with higher expression correlating with advanced stage malignancy, which suggests involvement of the protein in lung carcinogenesis."
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"This observation is consistent with a recent report that the over-expression of UCH-L1 induces testicular germ cell apoptosis in UCH-L1 transgenic mice."
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"In contrast , when CSMN are retrogradely transduced with AAV2-UCHL1-IRES-eGFP , which leads to the expression of both GFP and UCHL1 proteins , high level of UCHL1 expression is detected only in GFP + transduced CSMN ( Fig. 5d , g ) , confirming effective transduction and directed gene delivery only to CSMN ."
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