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Cation activates HCN4. 1 / 1
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"The hyper polarization-gated cyclic nucleotide cation-activated channel Hcn4 , a SAN specific molecular marker ( xref ; xref ), is expressed as early as E7.5 in mouse embryo, initially in the sinus horns of the sinus venosus, and becomes restricted to the SAN by E12.5 ( xref )."