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Cdk-4 increases the amount of UCHL5. 2 / 2
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"Additionally, we reveal that cyclin-dependent kinase 4/6 (CDK4/6) is involved in regulation of UCHL5 expression and that CDK4/6 inhibition decreases UCHL5 expression, resulting in suppression of MLL-r[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"As CDK4 or CDK6/Cyclin D complexes phosphorylate RB, we hypothesize that the reduction of UCHL5 expression by CDK4/6 inhibition can be attributed to the RB-E2F1 pathway."