IndraLab

Statements

EIF3F activates Hypertrophy. 4 / 4
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"Under basal conditions, overexpression of eIF3f in differentiated muscle cells is sufficient to induce hypertrophy via increased activity of mTORC1."
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"Moreover, overexpression of eIF3f K5-10R mutant induces a significant increase in protein synthesis and hypertrophy compared to the wild type protein under normal condition (Csibi et al., 2010 )."
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"Moreover, overexpression of eIF3f K5-10R mutant induces a significant increase in protein synthesis and hypertrophy compared to the wild type protein under normal condition (Csibi et al., 2010, Csibi et al., 2009)."
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"Genetic activation of eIF3f induces hypertrophy associated with an increase in phosphorylation of mTORC1 substrates S6K1 and 4E-BP1, and limits atrophy by increasing expression of muscle structural proteins during starvation (Csibi et al., 2010)."
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