IndraLab

Statements

RA190 binds UCHL5. 5 / 5
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reach
"We also report anti-cancer molecule RA190, which binds covalently to hRpn13 and UCHL5, to require hRpn13 Pru and not UCHL5 for cytotoxicity."
32631902
sparser
"We also scrutinized the dataset for evidence of RA190 binding to the Rpn13-associated deubiquitylase Uch37 as well."
32857985
sparser
"Thus, there are no compelling data from the isoTOP-ABPP experiment to indicate RA190 binding to Uch37 in cellulo ."
32857985
reach
"Biophysical analyses in combination with cell based assays indicate that RA190 directly binds and inactivates Uch37 [XREF_BIBR]."
32272746
reach
"RA190 binds Uch37 and inhibits its catalytic activity."
28598414