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"GDF3 was reported to be involved in both canonical pathways triggered by TGFB family members: (1) extracellular inhibition of BMPs xref and (2) induction of SMAD2/3 phosphorylation due to binding to Activin A receptors type IB or IC (ACVRIB, ACVRIC) and Activin A receptors type IIA or IIB (ACVRIIA, ACVRIIB) in cooperation with obligatory co-receptor teratocarcinoma-derived growth factor 1 (TDGF1) xref , xref ."