IndraLab

Statements

USP7 activates washc1. 3 / 3
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"To investigate how USP7 supports MAGE-L2-TRIM27 and WASH mediated protein recycling, we investigated whether USP7 controls the steady state levels or localization of any of the known components of the endosomal protein recycling pathway, including the important WASH actin assembly and retromer coat like complexes."
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"USP7 Acts as a Molecular Rheostat to Promote WASH Dependent Endosomal Protein Recycling and Is Mutated in a Human Neurodevelopmental Disorder."
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"Taken together, these findings suggest that the USP7 deubiquitinating enzyme forms a stable complex with the MAGE-L2-TRIM27 E3 ubiquitin ligase and that all three proteins work in concert to control W[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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