IndraLab

Statements

Notch decreases the amount of USP11. 3 / 3
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"However, it was recently demonstrated that Notch and Hey1 transcriptionally represses the expression of the PML deubiquitinase USP11, thereby down-regulating PML protein levels."
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"Since our previous study found that human USP11 transcription is repressed by the Notch pathway, the up-regulation of Usp11 is likely a consequence of Notch inactivation upon the induction of neuronal differentiation."
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"In line with this notion, we showed that mouse Usp11 was repressed by the Notch and Hes1 axis, as overexpression of an active form of Notch (Notch intracellular domain, referred to as NIC) or Hes1 in a neuroblastoma cell line N2a diminished Usp11 expression and the promoter activity of Usp11 gene."
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