IndraLab

Statements

FOXH1 inhibits CACNA1A. 10 / 10
| 10
sparser
"Yet, functionally, fhf is thought to modulate only voltage-dependent fast inactivation ( xref ; xref ; xref ), with changes in Ca 2+ -regulation unknown."
30198845
sparser
"FGF12 encodes a cytosolic protein that interacts with neuronal sodium channels and increases their voltage-dependent fast inactivation. xref Here, we performed WES-trio analysis and identified the same de novo missense mutation in 2 patients with severe neonatal-onset epilepsy and variable clinical outcomes."
27872899
sparser
"Compared to wild-type Cx43 (Cx43WT), Cx43(∗)NT37 junctions exhibited several functional alterations: extreme resistance to halothane- and acidification-induced uncoupling, absence of voltage-dependent fast inactivation, longer channel open times, larger unitary channel conductances, low junctional dye permeability/permselectivity, and an overall cation selectivity more typical of Cx37WT than Cx43WT junctions."
26745416
sparser
"The S5-P linker remains the most likely subdomain of the channel to confer voltage-dependent fast inactivation."
21376840
sparser
"In fact, modeling results showed that I NaT present a voltage dependent fast inactivation process that is the main contributor to the action potential repolarization and hence of is waveform, determining its frequency content of the spikes and its ability to pass through electrical contacts between these cells."
| PMC
sparser
"Depolarizing voltage clamp steps result in currents that appear to inwardly rectify due to voltage-dependent fast inactivation ( Smith et al., 1996; Spector et al., 1996; Schönherr and Heinemann, 1996[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10545354
sparser
"In contrast, a pronounced hyperpolarizing shift in voltage-dependent fast inactivation was observed for 30 μ M ( R )- 7 (21.4 mV in V 1/2 ) compared with a more modest change for 30 μ M ( R )- 11 (8.0 mV in V 1/2 )."
21765969
sparser
"I G185R rectified more steeply with voltage than I DMT1 , probably due to pronounced time- and voltage-dependent fast inactivation ( xref C; see xref for comparison)."
15024413
sparser
"In addition to slowing voltage-dependent activation, modulation by G-proteins has also been shown to decrease voltage-dependent fast inactivation ( xref )."
10694257
sparser
"As predicted from its location, L1563V in the neonatal isoform resulted in a depolarized shift in voltage-dependent fast inactivation, a reduced rate of entry into inactivation as well as faster recov[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17467289