IndraLab

Statements

P14_3_3 binds BRAF and RAF1. 4 / 4
| 4
sparser
"Although this appears to contradict our observation that dephosphorylation does not disrupt the complex, because 14-3-3 binds to BRAF and CRAF in a phosphorylation-dependent manner, we presume that 14-3-3 protects these sites from dephosphorylation."
20141835
sparser
"14–3-3 also binds pSer621 in C-Raf and Ser729 in B-Raf ( xref , xref , xref )."
33046444
sparser
"In B-Raf, Ser446 phosphorylation weakens the autoinhibition; 14–3-3 proteins bind to pSer259 in C-Raf (Raf-1) and pSer365 in B-Raf ( xref – xref ), stabilizing the autoinhibition."
33046444
sparser
"Further studies will be required to investigate how the differential and dynamic regulation of 14-3-3 binding to the conserved C-terminal sites in C-RAF and B-RAF ( Hekman et al., 2004 ) affects bindi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16364920