IndraLab

Statements

THBS1 activates SCARB2. 11 / 11
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"Activation of CD36 by TSP-1 phosphorylates p38 and JNK, which results in an increased expression of FasL and apoptosis ( xref ), which we saw in our tumor cells in response to ABT-510."
19139114
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"The requirement of TRPM2 for CD36 activation by oxLDL and TSP1 is an unexpected discovery."
35445217
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"As the expression of TSP1 was shown to be significantly increased in atherosclerotic aortas xref , our data suggest that TSP1 induced activation of CD36 signaling in macrophages may play an important role in macrophage activation during atherogenesis, and that the in vivo protective effects of TRPM2 deletion may partially be mediated by inhibiting TSP1 induced CD36 activation."
35445217
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"The trimeric TSP1 fragment that activates both CD148 and CD36 may be a powerful tool for anti-angiogenesis therapy."
27149518
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"Moreover, CD36 signaling activation in WT macrophages by TSP1 was inhibited by ACA, PJ34, and U73122 treatment ( xref , xref ), presumably through inhibiting TRPM2 activation."
35445217
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"Integrin-associated matricellular protein receptors such as CD47 and CD36 have recently been shown to be involved in pathological ROS production. xref Activation of CD47 and CD36 by thrombospondin-1 (TSP1) inhibits NO signaling xref in VSMCs and may contribute to eNOS uncoupling. xref Additionally, knockout studies of CD36 have implicated CD36 activity in the regulation of Nrf2 nuclear export and degradation, xref which ultimately results in higher levels of oxidative stress due to reduced antioxidant expression."
25634975
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"As an example, TSP1 may activate endothelial receptors CD36 or CD47 differentially or they can induce different responses depending on the type of integrin expressed; for instance, TSP1 inhibits endothelial migration in the microvasculature via binding with CD36 ( xref , xref ), but it could also enhance chemotaxis by binding to integrins α3β1and α6β1in HDMEV ( xref )."
33854480
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"Through its original mechanism of action which supposes concomitant disruption of TSP-1:CD47 interaction and enhancement of CD36 activation by TSP-1, TAX2 may inhibit tumor progression while limiting many of the undesired side effects of broadly inhibiting important physiological functions of CD47."
26578962
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"TSP-1 activates CD36, a transmembrane glycoprotein found on macrophages and endothelial cells [ xref , xref ]."
19481138
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"Moreover, we show that activation of CD36 by TSP-1 down-modulates the VEGF receptor-2 (VEGFR-2) and p38 mitogen-associated protein kinase phosphorylation induced by VEGF-A165, and this effect was specifically abolished by point mutation at C464."
16037098
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"Second, in higher concentrations TSP-1 binds and activates CD36, thereby decreasing intracellular cGMP-levels due to interaction with cellular uptake of myristic acid and decreased eNOS-dependent synthesis of nitric oxide [ xref ]."
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