IndraLab
Statements
sparser
"As the expression of TSP1 was shown to be significantly increased in atherosclerotic aortas xref , our data suggest that TSP1 induced activation of CD36 signaling in macrophages may play an important role in macrophage activation during atherogenesis, and that the in vivo protective effects of TRPM2 deletion may partially be mediated by inhibiting TSP1 induced CD36 activation."
sparser
"Integrin-associated matricellular protein receptors such as CD47 and CD36 have recently been shown to be involved in pathological ROS production. xref Activation of CD47 and CD36 by thrombospondin-1 (TSP1) inhibits NO signaling xref in VSMCs and may contribute to eNOS uncoupling. xref Additionally, knockout studies of CD36 have implicated CD36 activity in the regulation of Nrf2 nuclear export and degradation, xref which ultimately results in higher levels of oxidative stress due to reduced antioxidant expression."
sparser
"As an example, TSP1 may activate endothelial receptors CD36 or CD47 differentially or they can induce different responses depending on the type of integrin expressed; for instance, TSP1 inhibits endothelial migration in the microvasculature via binding with CD36 ( xref , xref ), but it could also enhance chemotaxis by binding to integrins α3β1and α6β1in HDMEV ( xref )."
sparser
"Through its original mechanism of action which supposes concomitant disruption of TSP-1:CD47 interaction and enhancement of CD36 activation by TSP-1, TAX2 may inhibit tumor progression while limiting many of the undesired side effects of broadly inhibiting important physiological functions of CD47."