IndraLab

Statements

HSP90 activates KCNH2. 4 / 5
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"For instance, the inhibition of the chaperone protein Hsp 90 prevents maturation and promotes the proteasome degradation of hERG protein, thereby reducing the number of mature channels that can be integrated into the cell membrane."
33345848
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"Inhibition of Hsp90 chaperone prevents maturation and increases proteasomal degradation of hERG, reducing the number of mature channels available to be incorporated into the cell membrane."
26926294
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"Hsp90 induced increase of functional HERG proteins was verified by their increased expression on the cell surface and enhanced HERG channel currents."
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"Inhibition of Hsp90 prevents maturation and reduces hERG and IKr currents."
16050262