IndraLab

Statements

ML277 activates KCNQ1. 7 / 7
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reach
"Structural insights for the modulation of KCNQ1 channel by ML277."
36783072
reach
"ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling."
31329101
reach
"This group [XREF_BIBR] later found that ML277 potentiates heteromultimeric KCNQ1 and KCNE1 channels but the increasing KCNE1 expression level reduced and eventually abolished ML277 's effect on KCNQ1 and KCNE1 channels, indicating a competition between KCNE1 and ML277 when interacting with KCNQ1."
33322401
reach
"Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277."
35768468
reach
"ML277 and R-L3 enhance KCNQ1 current amplitude and slow deactivation."
35957984
reach
"ML277 and R-L3 are two small-molecule activators of KCNQ1, the pore-forming subunit of the slowly activating potassium channel I Ks ."
35957984
eidos
"ML277 is a potent activator of KV7.1 ( Yu et al ., 2013 ) with a 100-fold increase in selectivity for KV7.1 compared to KV7.2-5 ( Yu et al ., 2013 ) ."
33364977