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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

ZUP1 inhibits STING1. 2 / 2

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"All three DUBs seem to prevent STING from proteasome-dependent degradation through uncoupling K48-linked ubiquitination after DNA virus infection ."

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reach

"Thus, these results are consistent with a role for viral DUB activity in antagonizing either the assembly or stability of STING dimers.Recent studies have revealed the arsenal of proteins that viruses use to evade and subvert recognition by pattern-recognition receptors (PRRs) or activation of signaling molecules that are designed to respond to infectious agents [45]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...