IndraLab

Statements

ZUP1 inhibits STING1. 2 / 2
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eidos
"All three DUBs seem to prevent STING from proteasome-dependent degradation through uncoupling K48-linked ubiquitination after DNA virus infection ."
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reach
"Thus, these results are consistent with a role for viral DUB activity in antagonizing either the assembly or stability of STING dimers.Recent studies have revealed the arsenal of proteins that viruses use to evade and subvert recognition by pattern-recognition receptors (PRRs) or activation of signaling molecules that are designed to respond to infectious agents [45]."
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