IndraLab

Statements

ROS1 binds SOS1 and GRB2. 3 / 3
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sparser
"To gain insight into the relationship between ROS1 fusion proteins and MAPK pathway, we performed coimmunoprecipitation analysis to look at the association of upstream MAPK activators GRB2 and SOS1 with ROS1."
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sparser
"In this study, we demonstrated that ROS1 fusion proteins can interact with the GRB2–SOS1 complex by coimmunoprecipitation studies."
32122926
sparser
"These results indicate that a direct interaction between ROS1 fusion protein with the GRB2–SOS1 complex plays an important role in the activation of MAPK pathway and the tumorigenic properties of ROS1 fusions."
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