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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CYLD activates TRAF2. 2 / 2

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"The regulation of TRAF2 signaling by CYLD was identified by screening an RNAi library targeting DUBs for ones that attenuate NFkappaB activation [XREF_BIBR] and through a two-hybrid screen for proteins that interact with the regulatory subunit of the IkappaB kinase complex that could also bind to TRAF2 [XREF_BIBR]."

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"In contrast to earlier studies, which had shown that CYLD acts as a Lys-63-specific DUB, Xue et al. found that CYLD removes Lys 48 polyubiquitin chains from TRAF2, thereby preventing TRAF2 proteolytic[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...