IndraLab

Statements

CYLD activates TRAF2. 3 / 3
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"Also, CYLD knocking-out macrophages could increase JNK activity through ubiquitinizing TRAF-2 protein, and studies have confirmed that CYLD knocking-out mice were prone to cancers [11, 12]."
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"The regulation of TRAF2 signaling by CYLD was identified by screening an RNAi library targeting DUBs for ones that attenuate NFkappaB activation [XREF_BIBR] and through a two-hybrid screen for proteins that interact with the regulatory subunit of the IkappaB kinase complex that could also bind to TRAF2 [XREF_BIBR]."
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"In contrast to earlier studies, which had shown that CYLD acts as a Lys-63-specific DUB, Xue et al. found that CYLD removes Lys 48 polyubiquitin chains from TRAF2, thereby preventing TRAF2 proteolytic[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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